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 Formulary Chapter 9: Nutrition and blood - Full Chapter
09.01.03  Expand sub section  Drugs used in hypoplastic, haemolytic, and renal anaemias
Eculizumab infusion
(Haemolytic uraemic syndrome)
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Formulary
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NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • As per NICE
  • RNOH:
    • Non-formulary
  • UCLH:
    • See links below
  • WH:
    • Non-formulary
 
Link  NICE HST1: Eculizumab for treating atypical haemolytic uraemic syndrome
Hydroxycarbamide
(Sickle cell)
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Formulary
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NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • Hydroxycarbamide Suspension 50mg/5ml (100 ml) unlicensed preparation is also available
  • RFL:
    • Restricted to Haematology
    • Not prescribed on Chemocare for this indication
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
09.01.03  Expand sub section  Erythropoietin
Darbepoetin alfa
(Aranesp)
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Restricted Drug Restricted
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Provider notes

  • NMUH:
    • For continuation of supply for those renal patients that have been initiated on treatment by Royal Free Hospital.
  • RFL:
    • Restricted to Renal team – preferred brand of erythropoietin
    • Restricted to Haematology for MDS
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • As per NICE TA 323
 
Link  NICE TA323: Erythropoiesis‑stimulating agents during chemotherapy
Epoetin alfa (Eprex)
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Restricted Drug Restricted
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Provider notes

  • NMUH:
    • For anaemia associated with chronic renal failure only.
    • Restricted to renal consultants signature and Dr. Tindall signature only.
    • Please note that the CSM has advised that the subcutaneous route is contraindicated in chronic renal failure. Please use the IV route instead. The dialysis unit has changed over to NeoRecormon which is an IV preparation.
  • RFL:
    • Restricted to Renal team - for patients who cannot tolerate darbepoetin or established patients only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Epoetin is available for treatment anaemia of renal disease only
 
Link  NICE TA323: Erythropoiesis‑stimulating agents during chemotherapy
Epoetin beta
(NeoRecormon)
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Restricted Drug Restricted
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Provider notes

  • NMUH:
    • Positive NICE TA This medicine has a positive NICE Technology Appraisal and is listed in the Trust Medicines Formulary when used  in line with NICE recommendations and/or Local Trust Guidelines.
    • Restricted to Renal and Haematology Consultants.
    • See MHRA drug safety updates 
  • RFL:
    • Restricted to Renal team - for patients who cannot tolerate darbepoetin or established patients only
    • Restricted to Haematology for MDS
  • RNOH:
    • Store in a refrigerator
  • UCLH:
  • WH:
    • Epoetin is available for treatment anaemia of renal disease only
    • Pre-filled syringe 2,000 units, 3,000 units, 4,000 units, 6,000 units, 10,000 units ONLY
 
Link  NICE TA323: Erythropoiesis‑stimulating agents during chemotherapy
Methoxy Polyethylene Glycol-Epoetin Beta
(Mircera)
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Restricted Drug Restricted
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Provider notes

  • NMUH:
    • Non-formulary.
  • RFL:
    • Restricted to renal team only - for patients who cannot tolerate darbepoetin or established patients only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
09.01.03  Expand sub section  Iron overload
Deferasirox
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Provider notes

  • NMUH:
    • See links below
  • RFL:
    • Commissioned as per NHS England policy for haemoglobinopathies.
    • Confirm with the commissioning team regarding other indications.
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NHSE 16070/P: Treatment of iron overload for transfused and non transfused patients with chronic inherited anaemias
Link  NMUH: The formulary awareness bulletin on defersirox (Exjade)
Deferiprone
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Restricted Drug Restricted
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Provider notes

  • NMUH:
    •  To be prescribed by the Haematology Team ONLY.
    • See links below
  • RFL:
    • Commissioned as per NHS England policy for haemoglobinopathies.
    • Confirm with the commissioning team regarding other indications.
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Tabs 500 mg ONLY
 
Link  NHSE 16070/P: Treatment of iron overload for transfused and non transfused patients with chronic inherited anaemias
Desferrioxamine Mesilate
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Restricted Drug Restricted
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Provider notes

  • NMUH:
    • To be prescribed by the Haematology Team ONLY.
    • See links below
  • RFL:
    • Commissioned as per NHS England policy for haemoglobinopathies.
    • Confirm with the commissioning team regarding other indications.
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NHSE 16070/P: Treatment of iron overload for transfused and non transfused patients with chronic inherited anaemias
 ....
 Non Formulary Items
Eculizumab infusion
(Paroxysmal nocturnal haemoglobinuria)

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Non Formulary
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NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Not approved for the treatment of paroxysmal nocturnal haemoglobinuria (PNH); see UCLH DTC minutes October 2007.

Epoetin alfa (Binocrit)

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Non Formulary
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Approved to treat anaemia (and prevent ribavirin dose reduction) in patients treated for hepatitis C virus (October 2013)

Epoetin theta
(Eporatio)

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Non Formulary
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Link  NICE TA323: Erythropoiesis‑stimulating agents during chemotherapy
Epoetin zeta (Retacrit)

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Non Formulary
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Link  NICE TA323: Erythropoiesis‑stimulating agents during chemotherapy
Oxymetholone

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Non Formulary
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
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Link to adult BNF
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Link to children's BNF
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Link to SPCs
Homecare
Homecare

Traffic Light Status Information

Status Description

GP - Amber

Medicines that should be initiated by a specialist. Prescribing can be transferred to primary care once the patient has been stabilised.

Shared care: For drugs with regular, ongoing need for monitoring and/or assessment of efficacy or toxicity. Prior agreement must be obtained by the specialist from the primary care provider before prescribing responsibility is transferred. The shared care protocol must have been agreed by the relevant secondary care trust Drugs and Therapeutics Committee(s) (DTC) and approved by the North Central London JFC.

Fact sheet: For drugs with some concerns surrounding safety or efficacy but do not require regular monitoring and/or monitoring of effectiveness/toxicity.

  

GP - Red

Medicines which should normally be prescribed by specialists only (hospital only).

For patients already receiving prescriptions in primary care - continue. No new patients to receive prescriptions in primary care.

See link for the complete NCL Red List https://www.ncl-mon.nhs.uk/wp-content/uploads/2017/08/ncl_red_list.pdf

  

Black

Medicines not recommended for routine use in primary or secondary care.

Medicines, which the North Central London JFC has actively reviewed and does not recommend for use at present due to limited clinical and/or cost effective data.

  

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