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 Formulary Chapter 5: Infections - Full Chapter
Notes:

Prescribing of systemic antimicrobials is 'protected'. All prescribing MUST be in accordance with the Trust Antimicrobial Policy and in conjunction with local antimicrobial guideline:

 Details...
05.03.01  Expand sub section  HIV infection
05.03.01  Expand sub section  Nucleoside reverse transcriptase inhibitors
Abacavir
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Restricted Drug Restricted
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • For TB / HIV clinic only
 
Abacavir + Lamivudine
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Restricted Drug Restricted
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • To be prescribed as per BHIVA Guidelines by the HIV team only
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • For TB / HIV clinic only
 
Abacavir + Lamivudine + Zidovudine
(Trizivir®)
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Formulary
GP - Red
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Emtricitabine
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Formulary
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • To be prescribed as per BHIVA Guidelines by the HIV team only
    • Patients currently benefiting from FTC in their combination therapy, who either accessed FTC in studies or move to London with FTC as part of their existing regimen, should continue to receive FTC without interruption
    • For patients who have previously not received 3TC, the decision to prescribe 3TC or FTC to be made by the clinician and patient after discussion and consideration of relevant factors
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • For TB / HIV clinic only
 
Emtricitabine + Rilpivirine + Tenofovir disoproxil
(Eviplera®)
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Restricted Drug Restricted
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • NHSE approval required
    • Initiation restricted to Consultants HIV Medicine
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Non-formulary
 
Emtricitabine + Tenofovir alafenamide
(Descovy®)
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Formulary
GP - Red
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Link  NHSE 16043/P: Tenofovir Alafenamide for treatment of HIV 1 in adults and adolescents
Lamivudine
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Restricted Drug Restricted
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • Epivir brand only approved for HIV patients
    • Zeffix brand approved for HIV and Hepatitis B patients
  • RFL:
    • 150mg & 300mg approved for HIV patients
    • 100mg approved for Hepatitis B patients
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Epivir brand on formulary
 
Rilpivirine
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Formulary
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Non-formulary
 
Stavudine
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Formulary
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Tenofovir disoproxil + Cobicistat + Elvitegravir + Emtricitabine
(Stribild®)
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Formulary
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • See MHRA Drug Safety Update
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • For TB / HIV clinic only
 
Link  NHSE B06/P/x: Stribild® for the treatment of HIV-1 infection in adults
Tenofovir disoproxil + Efavirenz + Emtricitabine
View adult BNF View SPC online View childrens BNF
Formulary
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • To be prescribed by the HIV team only, in line with the BHIVA Guidelines
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • For TB / HIV clinic only
 
Tenofovir disoproxil + Emtricitabine
View adult BNF View SPC online View childrens BNF
Formulary
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • To be prescribed by the HIV team only, in line with the BHIVA Guidelines
  • RFL:
    • HIV medicine only
  • RNOH:
    • Restricted for use in accordance with RNOH Sharps Policy and Inoculation Management (see policy)
  • UCLH:
  • WH:
    • No restriction stated
 
Link  RNOH: Sharps Policy and Inoculation Management
Tenofovir disproxil
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Formulary
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Approved for HIV
    • Approved for Hepatitis B - see NICE TA
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NICE TA173: Hepatitis B (chronic) - tenofovir disoproxil
Zidovudine
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Restricted Drug Restricted
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Zidovudine infusion is for use by Women’s Health only
    • Caps 100mg, 250mg; Infusion 200mg/2 ml only  
 
Zidovudine + Lamivudine
View adult BNF View SPC online View childrens BNF
Formulary
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • No restriction stated 
 
05.03.01  Expand sub section  Protease inhibitors
05.03.01  Expand sub section  Non-nucleoside reverse transcriptase inhibitors
05.03.01  Expand sub section  Other antiretrovirals to top
 ....
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
Homecare
Homecare

Traffic Light Status Information

Status Description

GP - 1st

Medicines suitable for first-line use within primary care.

Can be initiated within primary care within their licensed indication, in accordance with nationally recognised formularies, for example the BNF, BNF for Children, Medicines for Children or Palliative Care Formulary. Primary care prescribers take full responsibility for prescribing. 

  

GP - 2nd

Medicines suitable for second-line use within primary care.

Can be initiated within primary care within their licensed indication, in accordance with nationally recognised formularies, for example the BNF, BNF for Children, Medicines for Children or Palliative Care Formulary. Primary care prescribers take full responsibility for prescribing. 

  

GP - Amber

Medicines that should be initiated by a specialist. Prescribing can be transferred to primary care once the patient has been stabilised.  

Shared care: For drugs with regular, ongoing need for monitoring and/or assessment of efficacy or toxicity. Prior agreement must be obtained by the specialist from the primary care provider before prescribing responsibility is transferred. The shared care protocol must have been agreed by the relevant secondary care trust Drugs and Therapeutics Committee(s) (DTC) and approved by the North Central London JFC.

Fact sheet: For drugs with some concerns surrounding safety or efficacy but do not require regular monitoring and/or monitoring of effectiveness/toxicity.

  

GP - Red

Medicines which should normally be prescribed by specialists only (hospital only).

For patients already receiving prescriptions in primary care - continue. No new patients to receive prescriptions in primary care.

See link for the complete NCL Red List https://www.ncl-mon.nhs.uk/wp-content/uploads/2017/08/ncl_red_list.pdf

  

GP - Grey

Medicines on hospital formularies which have not been reviewed for suitability in primary care.  

Black

Medicines not recommended for routine use in primary or secondary care.

Medicines, which the North Central London JFC has actively reviewed and does not recommend for use at present due to limited clinical and/or cost effective data.

  

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