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 Formulary Chapter 5: Infections - Full Chapter
Notes:

Prescribing of systemic antimicrobials is 'protected'. All prescribing MUST be in accordance with the Trust Antimicrobial Policy and in conjunction with local antimicrobial guideline:

 Details...
05.01  Antibacterial drugs
05.01  Table 1. Summary of antibacterial therapy
05.01  Table 2. Summary of antibacterial prophylaxis
05.01.01  Penicillins
05.01.01.01  Benzylpenicillin and phenoxymethylpenicillin to top
Benzylpenicillin
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • No restriction stated
 
Phenoxymethylpenicillin
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • No restriction stated
 
Benzathine benzylpenicillin
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Unlicensed Drug Unlicensed
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Provider notes

  • NMUH:
    • Used in the treatment of early syphilis and late latent syphilis
    • Benzathine Benzylpenicillin 2.4 mega unit injection, available from ‘special-order’ manufacturers or specialist importing companies
  • RFL:
    • Microbiology/ID approval only
  • RNOH approvals
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Procaine Penicillin G Injection
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Unlicensed Drug Unlicensed
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Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Restricted to Micro/ID recommendation only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
05.01.01.02  Penicillinase-resistant penicillins
Flucloxacillin
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • No restriction stated
 
Temocillin
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Restricted Drug Restricted
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Store in a refrigerator

Provider notes

  • NMUH:
    • Consultant Microbiologist recommendation only
  • RFL:
    • See Microguide for agreed indications
    • Microbiology/ID approval required for all other indications
  • RNOH:
    • Approved for ESBL infections. Restricted to Microbiology recommendation only
  • UCLH:
  • WH:
    • Microbiology approval required
 
05.01.01.03  Broad-spectrum penicillins
Amoxicillin
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • Oral suspension available as 125 mg/5mL and 250 mg/5mL
  • UCLH:
  • WH:
    • No restriction stated
 
Co-Amoxiclav
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • Oral suspension available as 125/31.25 mg/5mL and 250/62.5 mg/5mL
  • UCLH:
  • WH:
    • No restriction stated
 
05.01.01.04  Antipseudomonal penicillins
Piperacillin + Tazobactam
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Restricted Drug Restricted
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • As per RFL microbiology guidelines
    • ITU - microbiology approval required within 48 hours for other uses
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Check with microbiology
 
05.01.01.05  Mecillinams
Pivmecillinam
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Restricted Drug Restricted
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Approved for uncomplicated UTI linked to suspected/proven ESBL (JFC November 2015) 

Provider notes

  • NMUH:
    • Restricted. Microbiology advice only
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • Restricted for suspected or proven ESBL only
  • UCLH:
  • WH:
    • No restriction stated
 
05.01.02  Cephalosporins, carbapenems and other beta-lactums to top
05.01.02  Cephalosporins
05.01.02  Other beta-lactam antibiotics
05.01.02.01  Cephalosporins
Cefalexin
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • See Microguide for approved indications
    • Microbiology/ID approval required for all other indications
  • RNOH:
    • Oral suspension available as 250 mg/5mL
  • UCLH:
  • WH:
    • No restriction stated
 
Cefazolin
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Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Approved for surgical prophylaxis
    • Microbiology/ID approval required for all other indications
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Cefixime
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Provider notes

  • NMUH:
    • Restricted to Consultants in GU Medicine.
  • RFL:
    • Restricted to GUM
    • Microbiology/ID approval required for all other indications
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Cefotaxime
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Provider notes

  • NMUH:
    • Restricted to Microbiology approval only
  • RFL:
    • See Microguide for approved indications. Approved for Neonatal unit
    • Microbiology/ID approval required for all other indications
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Restricted to Paediatrics and Neonatal use only
 
Ceftazidime
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Provider notes

  • NMUH:
    • Restricted to Microbiology approval only
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • For restricted indications as per Trust guidelines or Microbiology advice
 
Ceftazidime + Avibactam
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Approved for the treatment of infections caused by non-MBL carbapenemase-producing aerobic Gram-negative organisms, that have proven susceptibly to ceftazidime-avibactam and where the only alternative active agents, if any, are limited to colistin, tigecycline and fosfomycin, which cannot be used due to resistance or intolerance - Microbiology recommendation only (JFC August 2017)

Provider notes

  • NMUH:
    • Microbiology approval only
  • RFL:
    • Consultant Microbiology/ID approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Restricted antibiotics. Microbiology approval only
 
Ceftolozane + tazobactam
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Approved for multi-resistant Gram-negative organisms that have proven susceptibly to ceftolozane-tazobactam and where the only alternative active agents, if any, are limited to colistin, tigecycline and fosfomycin (JFC September 2016)

Provider notes

  • NMUH:
    • Microbiology recommendation ONLY
  • RFL:
    • Consultant Microbiology/ID approval only
  • RNOH:
    • Consultant Microbiology Approval only
  • UCLH:
  • WH:
    • Restricted antibiotics. Microbiology approval only
 
Ceftriaxone
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Provider notes

  • NMUH:
    • Restricted to use in paediatrics for sepsis and meningitis
  • RFL:
    • See Microguide for agreed indications
    • Microbiology/ID approval required for all other indications
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • For restricted indications as per Trust guidelines or Microbiology advice
 
Cefuroxime
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Provider notes

  • NMUH:
    • Restricted to Microbiology approval only
    • Injection is formulary
    • Tablets are non-formulary
  • RFL:
    • See Microguide for approved indications
    • Microbiology/ID approval required for all other indications
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Non-formulary
 
05.01.02.02  Carbapenems
Ertapenem
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Provider notes

  • NMUH:
    • Microbiology approval only
  • RFL:
    • Microbiology approval only (except ITU, microbiology approval required within 48 hours)
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • Restricted antibiotic - Microbiology approval only
 
Imipenem + Cilastatin
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Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Microbiology approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Meropenem
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Provider notes

  • NMUH:
    • Microbiology approval only
  • RFL:
    • Restricted to Neutropenic sepsis (penicillin allergy) and ITU (microbiology approval required within 48 hours)
    • Microbiology approval for all other indications
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Microbiology approval only
 
05.01.02.03  Other beta-lactams antibiotics to top
Aztreonam
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Provider notes

  • NMUH:
    • Consultant Microbiologist recommendation only
  • RFL:
    • Microbiology approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
05.01.03  Tetracyclines
Demeclocycline
(Antibiotic)
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NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
    • ???
  • WH:
    • Microbiology approval only
 
Doxycycline
(Antibiotic)
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Formulary
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NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Oral: See Microguide for approved indications
    • IV: Seek Microbiology, ID or Pharmacy advice before prescribing
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • No restriction stated
 
Lymecycline
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Reserved for Dermatology use only
 
Minocycline
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Restricted to Dermatology and Rheumatology for calcinosis
    • Microbiology approval required for all other indications
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Check with Microbiology
 
Minocycline modified release
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Provider notes

  • NMUH:
    • for Dermatology use ONLY
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • ???Reserved for Dermatology use only
 
Oxytetracycline
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • For Microbiology use only
 
Tetracycline
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Reserved for H.pylori treatment in penicillin allergy
 
05.01.03  Tigecycline
Tigecycline
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Restricted Drug Restricted
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Provider notes

  • NMUH:
    • Consultant Microbiologist recommendation only
  • RFL:
    • Microbiology approval only
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • Microbiology approval only
 
05.01.04  Aminoglycosides
Amikacin injection
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Provider notes

  • NMUH:
    • Restricted to Microbiology approval only
  • RFL:
    • Refer to amikacin prescribing guidelines in Microguide
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Microbiology approval only
 
Gentamicin injection
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Refer to gentamicin prescribing guidelines in Microguide
  • RNOH:
    • Different brands of gentamicin 80mg in 2mL vials are stocked at RNOH
    • The Amdipharm, Hospira and Sanofi brands are licensed for administration intramuscularly (IM) and intravenously (IV) and will be kept as stock in all ward areas.
    • The Wockhardt brand is licensed for intravenous route (IV) only and will be stocked in Theatres only. This formulation must not be administered intramuscularly.
  • UCLH:
  • WH:
    • No restriction stated
 
Neomycin tablets
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Provider notes

  • NMUH:
    • Non-formulary  
  • RFL:
    • Restricted to Colorectal Surgery
    • Microbiology/ID approval required for all other indications
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Paromomycin
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Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Microbiology/ID consultant approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Tobramycin injection
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Provider notes

  • NMUH:
    • Microbiologist approval only
  • RFL:
    • Microbiologist approval only
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • Non-formulary
 
05.01.05  Macrolides
Azithromycin tabs/caps/suspension
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Refer to Microguide for agreed indications, all other indications require microbiology approval
    • Used for prophylaxis and treatment of Mycobacterium avium intracellulare in HIV
  • RNOH:
    • Oral suspension available as 200 mg/5mL
  • UCLH:
  • WH:
    • Suspension is reserved for Paediatric and Neonatal use only
 
Clarithromycin
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • Microbiologist approval only
    • Oral suspension available as 250 mg/5mL
  • UCLH:
  • WH:
    • No restriction stated
 
Erythromycin
(Anti-infective)
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NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • Injection is reserved for the use of Paediatrics only
  • RFL:
    • No restriction stated
  • RNOH:
    • Oral suspension available as 125 mg/5mL and 250 mg/5mL
  • UCLH:
  • WH:
    • Restricted to Maternity use or as prokinetic
 
05.01.06  Clindamycin to top
Clindamycin
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • As per RFL policy on microguide
    • Microbiology approval required for all other indications
    • Used for prophylaxis and treatment of Mycobacterium avium intracellulare in HIV
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Microbiology approval only
 
05.01.07  Some other antibacterials
Dalbavancin infusion
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Approved if recommended by Microbiology for skin and soft tissue infections in patients only if (JFC April 2017):

  • unable to receive oral therapy and
  • available treatment pathways for repeated IV antibiotics are unsuitable e.g. chaotic lifestyle, immobility, poor venous access

Provider notes

  • NMUH:
    • On microbiology recommendation only
  • RFL:
    • Restricted to Microbiology Consultant only
  • RNOH:
    • Non-formulary
  • UCLH:
    • Skin and soft tissue infections in patients unable to receive oral therapy- Restricted to Microbiology recommendation (JFC April 2017)
  • WH:
    • As above (restricted to Microbiology)
 
Rifaximin (Xifaxanta®)
(SIBO)
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GP - Red
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Approved for small intestine bacterial overgrowth (SIBO) in patients with systemic sclerosis (SSc) only (JFC June 2019)

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Approved for use in the treatment of small intestinal bacterial overgrowth (SIBO) in systemic sclerosis (SSc) patients only
  • RNOH:
    • Non-formulary
  • UCLH:
    • Non-formulary
  • WH:
    • Approved for use in the treatment of small intestinal bacterial overgrowth (SIBO) in systemic sclerosis (SSc) patients only
 
05.01.07  Chloramphenicol
Chloramphenicol
(Systemic)
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Provider notes

  • NMUH:
    • Chloramphenicol capsules are non-formulary
    • To be used as per the Trust guidelines for Management of Acute Bacterial Meningitis 
  • RFL:
    • As per agreed indications on microguide
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Microbiology approval only
 
05.01.07  Fosfomycin
Fosfomycin oral sachets
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Approved for prescribing in primary and secondary care for symptomatic UTI sensitive to fosfomycin, where patients are unable to receive, or the organism is resistant to, first-line antibiotics (July 2015)

Provider notes

  • NMUH:
    • Consultant Microbiology approval only
  • RFL:
    • See Microguide for approved indications
    • Microbiology/ID approval required for all other indications
  • RNOH:
    • Microbiology approval only
  • UCLH:
  • WH:
    • Microbiology approval only
 
Fosfomycin intravenous
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Microbiology approval only for treatment of infections, or suspected infections, caused by multi-drug resistant Gram-negative organisms, including ESBLs (JFC August 2016)

Provider notes

  • NMUH:
    • Should only be prescribed following advice from a Consultant Microbiologist
  • RFL:
    • Consultant Microbiology/ID approval only
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Microbiology approval only
 
05.01.07  Fusidic acid
Sodium fusidate
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Provider notes

  • NMUH:
    • Microbiology approval only
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Microbiology approval only
 
05.01.07  Vancomycin and teicoplanin to top
Teicoplanin
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Provider notes

  • NMUH:
    • Microbiology approval only
  • RFL:
    • See microbiology guidelines for agreed indications
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Restricted to OPAT and theatres
 
Vancomycin intravenous
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Provider notes

  • NMUH:
    • Microbiology approval only
  • RFL:
    • Refer to vancomycin prescribing guidelines in Microguide
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Check with Microbiology
 
Vancomycin oral
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Provider notes

  • NMUH:
    • Microbiology approval only
  • RFL:
    • Injection used orally: Refer to Microguide for C. difficile treatment (injection is licensed for oral use and should be used for inpatients) 
    • Capsules: Outpatient and discharge prescribing only
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Microbiology approval only
 
05.01.07  Daptomycin
Daptomycin
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Store in a refrigerator

Provider notes

  • NMUH:
    • Consultant Microbiologist approval only
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • Microbiology approval only
  • UCLH:
  • WH:
    • Microbiology approval only
 
05.01.07  Linezolid
Linezolid
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Provider notes

  • NMUH:
    • Microbiology approval only
  • RFL:
    • Microbiology/ID approval required
  • RNOH:
    • Microbiology approval only
  • UCLH:
  • WH:
    • Microbiology approval only
 
05.01.07  Quinupristin and dalfopristin
05.01.07  Polymyxins
Colistimethate for nebulisation
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Restricted Drug Restricted
High Cost Medicine
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Provider notes

  • NMUH:
    • Microbiology recommendation only
  • RFL:
    • Consultant Microbiology/ID approval only
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • Check with Microbiology
 
Colistimethate injection
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Provider notes

  • NMUH:
    • Microbiology recommendation only
  • RFL:
    • Consultant Microbiology/ID approval only
  •  RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • Check with Microbiology
 
05.01.07  Rifaximin to top
Rifaximin (Targaxan®)
(Encephalopathy)
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GP - Amber
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Provider notes

  • NMUH:
    • This medicine has a positive NICE Technology Appraisal and is listed in the Trust Medicines Formulary when used in line with NICE recommendations and/or Local Trust Guidelines.
    • Access Trust guideline via intranet
    • To be prescribed by the Gastroenterology team
  • RFL:
    • To be prescribed by the gastro/hepatology teams for use in the treatment of hepatic encephalopathy  - see local policy
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Gastroenterology approval only - hepatic encephalopathy.
 
Link  NCL JFC: Shared Care Guideline Rifaximin (Targaxan®) Treatment of hepatic encephalopathy
Link  NICE TA337: Rifaximin for preventing episodes of overt hepatic encephalopathy
05.01.07  Fidaxomicin
Fidaxomicin
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Consultant microbiologist approval only for multiple recurrent Clostridium difficile infections (at least three). Fidaxomicin could also be used in patients in extremis when all other drugs had failed (October 2012)

Provider notes

  • NMUH:
    • Microbiology approval only
  • RFL:
    • Consultant microbiologist approval only  
  • RNOH:
    • Microbiology approval only
  • UCLH:
  • WH:
    • Microbiology approval only
 
05.01.08  Sulphonamides and trimethoprim
Co-trimoxazole
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • See Microguide for agreed indications
    • Approved for treatment and prevention of PCP infection; see Chemotherapy protocols
    • Microbiology or ID approval required for other indications
  • RNOH:
    • Oral suspension available as 40/200 mg/5mL and 80/400 mg/5mL
  • UCLH:
  • WH:
    • Microbiology approval only
 
Trimethoprim
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Formulary
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • No restriction stated
 
05.01.09  Antituberculosis drugs
Bedaquiline
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Formulary
GP - Red
High Cost Medicine
BlueTeq
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Approved for XDR-TB and MDR-TB in line with the NHS England Clinical Commissioning Policy F04/P/a (JFC April 2017)

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Approved for XDR-TB and MDR-TB in line with NHSE policy
    • Restricted to ID team only
  • RNOH:
    • Non-formulary  
  • UCLH:
    • Pulmonary multidrug-resistant tuberculosis in line with NHS England policy, restricted to TB team
  • WH:
    • As above
 
Link  NHSE 170132P: Treatment for defined patients with MDR-TB and XDR-TB including bedaquiline and delamanid
Capreomycin
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Restricted Drug Restricted
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Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Microbiology/ ID approval only (TB treatment)
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Restricted to TB clinic or as per Microbiology advice
 
Cycloserine
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Restricted Drug Restricted
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Provider notes

  • NMUH:
    • Restricted for the use in combination with other drugs for Tuberculosis resistant to first line drugs only
  • RFL:
    • Microbiology/ ID approval only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Restricted to TB clinic or as per Microbiology advice
 
Delamanid
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Restricted Drug Restricted
GP - Red
High Cost Medicine
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Approved for XDR-TB and MDR-TB in line with the NHS England Clinical Commissioning Policy F04/P/a (JFC April 2017)

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • As per NHSE policy for XDR-TB and MDR-TB
  • RNOH:
    • Non-formulary  
  • UCLH:
    • Pulmonary multidrug-resistant tuberculosis in line with NHS England policy, restricted to TB team
  • WH:
    • TB clinic only
 
Link  NHSE 170132P: Treatment for defined patients with MDR-TB and XDR-TB including bedaquiline and delamanid
Ethambutol
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Restricted Drug Restricted
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Provider notes

  • NMUH:
    • No restriction stated (suspension 400mg/5ml [unlicensed] is available for the treatment of tuberculosis in children)
  • RFL:
    • For treatment of tuberculosis only
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • No restriction stated
 
Isoniazid
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Restricted Drug Restricted
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Provider notes

  • NMUH:
    • No restriction stated (Isoniazid elixir 50mg/5mL [unlicensed] available for the treatment of tuberculosis in children)
  • RFL:
    • For treatment and prophylaxis of tuberculosis only
    • Microbiology or ID approval required for other indications
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • No restriction stated
 
Pyrazinamide
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Restricted Drug Restricted
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Provider notes

  • NMUH:
    • No restriction stated (pyrazinamide 500mg/5mL suspension [unlicensed] available for the treatment of tuberculosis in children)
  • RFL:
    • For treatment of tuberculosis only  
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • No restriction stated
 
Rifabutin
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Restricted Drug Restricted
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Provider notes

  • NMUH:
    • Restricted to AIDS patients use only
  • RFL:
    • For HIV / TB Consultant use only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • For HIV / TB Consultant use only
 
Rifampicin
(Antibacterial)
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Restricted Drug Restricted
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NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • For treatment of tuberculosis only
    • Microbiology/ID approval required for all other indications
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Microbiology approval only
 
Rifampicin + Isoniazid
(Rifinah® 150 & 300)
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Restricted Drug Restricted
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • For treatment of tuberculosis only
    • Microbiology/ID approval only
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • No restriction stated
 
Rifampicin + Isoniazid + Pyrazinamide
(Rifater®)
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Restricted Drug Restricted
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • For treatment of tuberculosis only
    • Microbiology/ID approval only
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • TB / Microbiology approval only
 
Rifampicin + Isoniazid + Pyrazinamide + Ethambutol
(Voractiv®)
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Formulary
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Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • For treatment of tuberculosis only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Aminosalicylic acid
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Unlicensed Drug Unlicensed
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Provider notes

  • NMUH:
    • Available from 'special order' manufacturers
  • RFL:
    • Available from 'special order' manufacturers
    • MDR-TB only
    • Restricted to ID / Microbiology
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Protionamide
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Unlicensed Drug Unlicensed
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Provider notes

  • NMUH:
    • For Multidrug resistent TB
    • To be prescribed by Respiratory Consultants ONLY
    • Protionamide 250mg tablets, Available from ‘special-order’ manufacturers or specialist importing companies
  • RFL:
    • Available from 'special order' manufacturers
    • MDR-TB only
    • Restricted to ID / Microbiology
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • For specialist use only
 
05.01.10  Antileprotic drugs
Clofazimine
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Restricted Drug Restricted
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Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Microbiology approval only
 
Dapsone
(Anti-infective)
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
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NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
05.01.11  Metronidazole and tinidazole to top
Metronidazole
(Antibacterial)
View adult BNF View SPC online View childrens BNF
Formulary
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NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • No restriction stated
 
Tinidazole
(Antibacterial)
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
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NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
05.01.12  Quinolones
Ciprofloxacin
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Restricted Drug Restricted
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • See microguide for agreed indications
    • Microbiology approval required for all other indications
  • RNOH:
    • Oral suspension available as 250 mg/5mL
  • UCLH:
  • WH:
    • For restricted indications as per Trust guidelines or Microbiology advice
 
Link  NCL JFC: Safe prescribing of fluoroquinolones Position Statement
Levofloxacin
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Restricted Drug Restricted
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Provider notes

  • NMUH:
    • Restricted to Consultant Microbiologist or Consultant Gastroenterologist recommendation
  • RFL:
    • Follow RFL microbiology guidelines for agreed indications
    • Microbiology approval required for all other indications
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • For restricted indications as per Trust guidelines or Microbiology advice
 
Link  NCL JFC: Safe prescribing of fluoroquinolones Position Statement
Moxifloxacin
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Restricted Drug Restricted
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Provider notes

  • NMUH:
    • Restricted to microbiology and respiratory consultants
  • RFL:
    • Restricted to thoracic medicine / ID (TB) and Opthalmology
    • ID/Microbiology approval required for all other indications
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • For restricted indications as per Trust guidelines or Microbiology advice
 
Link  NCL JFC: Safe prescribing of fluoroquinolones Position Statement
Ofloxacin
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Restricted Drug Restricted
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Provider notes

  • NMUH:
    • Approved for symptomatic gonorrhoea and pelvic inflammatory disease only
  • RFL:
    • Restricted to GUM
    • ID/Microbiology approval required for all other indications
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Link  NCL JFC: Safe prescribing of fluoroquinolones Position Statement
05.01.13  Urinary-tract infections
Methenamine hippurate
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Formulary
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Approved for recurrent UTIs in adults who have experienced ≥ 2 UTIs in the last 6 months, or ≥ 3 in the last 12 months (JFC April 2017)

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • As per above JFC agreed indication  
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Nitrofurantoin
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Formulary
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Provider notes

  • NMUH:
    • See MHRA Drug Safety Update
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Nitrofurantoin suspension is restricted to paediatric patients unable to swallow tablets 
 
Nitrofurantoin modified release
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Formulary
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Provider notes

  •  NMUH:
    • Non-formulary
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
    • Non-formulary
  •  WH:
    • No restriction stated
 
05.02  Antifungal drugs
Amphotericin infusion
(Fungizone®)
View adult BNF View SPC online View childrens BNF
Formulary
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Not for intravenous use
    • Microbiology/ID approval only
  • RNOH:
    • Non-formulary
  • UCLH:
    • Approved for:
      • Cryptococcosis – treatment (Restricted to Microbiology approval)
      • Serious fungal infections (Restricted to Microbiology approval for intraventricular disease)
  • WH:
    • Non-formulary
 
Amphotericin liposomal infusion
(AmBisome®)
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
High Cost Medicine
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Provider notes

  • NMUH:
    • As per Trust Guidelines
  • RFL:
    • Restricted to OLT prophylaxis (2nd transplant/hepatic artery thrombosis)
    • Microbiology/ID approval required for all other indications
  • RNOH:
    • Microbiology approval only
  • UCLH:
  • WH:
    • Microbiology approval only
 
Fluconazole
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Restricted Drug Restricted
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Provider notes

  • NMUH:
    • Infusion restricted to Microbiology Consultants use only
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Restricted antifungal. Microbiology approval only
 
Flucytosine infusion
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Restricted Drug Restricted
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Provider notes

  • NMUH:
    • Restricted to Microbiology Consultants use only
  • RFL:
    • Microbiology / ID approval required 
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Microbiology approval only
 
Griseofulvin
View adult BNF View SPC online View childrens BNF
Formulary
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • No restriction stated
 
Isavuconazole capsules/infusion
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Formulary
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Approved for treatment of proven or probable invasive aspergilosis or mucomycosis where other antifungals are not appropriate (JFC August 2020)

 

Provider notes

  • NMUH:
    • As per JFC decision above
    • On microbiology recommendation ONLY
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Itraconazole
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Oral: Restricted to Dermatology; HIV; Haematology. ID/Microbiology approval for all other indications.
    • Intravenous: Microbiology/ID approval
  • RNOH:
    • Microbiology approval only
  • UCLH:
  • WH:
    • For restricted indications as per Trust guidelines or Microbiology advice
 
Posaconazole
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • Non-formulary
    • See MHRA Drug Safety Updates
  • RFL:
    • Liquid: Restricted to Haematology and Oncology for prophylaxis; Microbiology approval required for treatment doses and all other indications
    • Tablets: Microbiology/ID approval required
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Terbinafine tabs
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
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Provider notes

  • NMUH:
    • Restricted to Dermatology use only
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • No restriction stated
 
Voriconazole
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • Microbiology approval required
    • See MHRA Drug Safety Updates
  • RFL:
    • Microbiology approval required 
  • RNOH:
    • Microbiology approval required
  • UCLH:
  • WH:
    • Check with Microbiology
 
Flucytosine tablets
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed
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Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Microbiology / ID approval required
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • 500mg tablets
 
05.02  Treatment of fungal infections
05.02  Drugs used in fungal infections to top
05.02.01  Triazole antifungals
05.02.02  Imidazole antifungals
05.02.03  Polyene antifungals
05.02.04  Echinocandin antifungals
Anidulafungin
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Restricted Drug Restricted
GP - Red
High Cost Medicine
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Approved for invasive candidiasis, subject to local Antimicrobial Committee approval (JFC February 2019).

Provider notes

  • NMUH:
    • To be used as per Trust antifungal guidelines
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Microbiology approval only
 
Caspofungin
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • Microbiology consultant approval only
  • RFL:
    • See Microguide for agreed indications
    • Restricted to Haematology / Oncology as per policy
    • Microbiology approval required for all other indications.
  • RNOH:
    • Microbiology approval only
    • Store in a fridge
  • UCLH:
  • WH:
    • Reserved for prescribing by paediatric consultants only
 
05.02.05  Other antifungals to top
05.03  Antiviral drugs
05.03.01  HIV infection
Atazanavir + cobicistat
(Evotaz®)
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • To be initiated by Consultants in HIV Medicine only
  • RFL:
    • HIV Medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Non-formulary
 
Rilpivirine + emtrictabine + tenofovir alafenamide
(Odefsey®)
View adult BNF View SPC online View childrens BNF
Formulary
GP - Red
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 Secondary care notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Link  NHSE 16043/P: Tenofovir Alafenamide for treatment of HIV 1 in adults and adolescents
Tenofovir alafenamide + Elvitegravir + Cobicistat + Emtricitabine
(Genvoya®)
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • To be initiated by consultants in HIV medicines only
    • See MHRA Drug Safety Update
    • See link below
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Link  NHSE 16043/P: Tenofovir Alafenamide for treatment of HIV 1 in adults and adolescents
05.03.01  Nucleoside reverse transcriptase inhibitors
Abacavir
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • For TB / HIV clinic only
 
Abacavir + Lamivudine
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • To be prescribed as per BHIVA Guidelines by the HIV team only
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • For TB / HIV clinic only
 
Abacavir + Lamivudine + Zidovudine
(Trizivir®)
View adult BNF View SPC online View childrens BNF
Formulary
GP - Red
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Emtricitabine
View adult BNF View SPC online View childrens BNF
Formulary
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • To be prescribed as per BHIVA Guidelines by the HIV team only
    • Patients currently benefiting from FTC in their combination therapy, who either accessed FTC in studies or move to London with FTC as part of their existing regimen, should continue to receive FTC without interruption
    • For patients who have previously not received 3TC, the decision to prescribe 3TC or FTC to be made by the clinician and patient after discussion and consideration of relevant factors
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • For TB / HIV clinic only
 
Emtricitabine + Rilpivirine + Tenofovir disoproxil
(Eviplera®)
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • NHSE approval required
    • Initiation restricted to Consultants HIV Medicine
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Non-formulary
 
Emtricitabine + Tenofovir alafenamide
(Descovy®)
View adult BNF View SPC online View childrens BNF
Formulary
GP - Red
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Link  NHSE 16043/P: Tenofovir Alafenamide for treatment of HIV 1 in adults and adolescents
Lamivudine
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • Epivir brand only approved for HIV patients
    • Zeffix brand approved for HIV and Hepatitis B patients
  • RFL:
    • 150mg & 300mg approved for HIV patients
    • 100mg approved for Hepatitis B patients
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Epivir brand on formulary
 
Rilpivirine
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Formulary
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Non-formulary
 
Stavudine
View adult BNF View SPC online View childrens BNF
Formulary
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Tenofovir disoproxil + Cobicistat + Elvitegravir + Emtricitabine
(Stribild®)
View adult BNF View SPC online View childrens BNF
Formulary
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • See MHRA Drug Safety Update
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • For TB / HIV clinic only
 
Link  NHSE B06/P/x: Stribild® for the treatment of HIV-1 infection in adults
Tenofovir disoproxil + Efavirenz + Emtricitabine
View adult BNF View SPC online View childrens BNF
Formulary
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • To be prescribed by the HIV team only, in line with the BHIVA Guidelines
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • For TB / HIV clinic only
 
Tenofovir disoproxil + Emtricitabine
View adult BNF View SPC online View childrens BNF
Formulary
GP - Red
High Cost Medicine
AAAAAAAA

Provider notes

  • NMUH:
    • To be prescribed by the HIV team only, in line with the BHIVA Guidelines
  • RFL:
    • HIV medicine only
  • RNOH:
    • Restricted for use in accordance with RNOH Sharps Policy and Inoculation Management (see policy)
  • UCLH:
  • WH:
    • No restriction stated
 
Link  RNOH: Sharps Policy and Inoculation Management
Tenofovir disproxil
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Formulary
GP - Red
High Cost Medicine
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Approved for HIV
    • Approved for Hepatitis B - see NICE TA
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NICE TA173: Hepatitis B (chronic) - tenofovir disoproxil
Zidovudine
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
GP - Red
High Cost Medicine
AAAAAAAA

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Zidovudine infusion is for use by Women’s Health only
    • Caps 100mg, 250mg; Infusion 200mg/2 ml only  
 
Zidovudine + Lamivudine
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • No restriction stated 
 
05.03.01  Protease inhibitors
Atazanavir
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Provider notes

  • NMUH:
    • To be prescribed as per BHIVA Guidelines by HIV team only
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • No restriction stated
 
Darunavir
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Provider notes

  • NMUH:
    • To be prescribed as per BHIVA Guidelines by the HIV team only
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • For TB / HIV clinic only
 
Darunavir + Cobicistat
(Rezolsta®)
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Provider notes

  • NMUH:
    • To be initiated by Consultants in HIV Medicine only
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Non-formulary
 
Darunavir + Cobicistat + Emtricitabine + Tenofovir alafenamide
(Symtuza®)
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Formulary
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Approved for HIV infection in line with NHSE commissioning policy F03/P/b (JFC January 2019)

 Provider notes

  • NMUH:
    • To be prescribed by the HIV team only, as per the clinical commissioning policy - see link below.
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • As above
 
Link  NHSE F03/P/b: Use of cobicistat as a booster in treatment of HIV infection (all ages)
Fosamprenavir
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • No restriction stated
 
Lopinavir + Ritonavir
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Provider notes

  • NMUH:
    • Check Drug Safety Update
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • For TB / HIV clinic only
 
Ritonavir
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • For TB / HIV clinic only
 
Saquinavir
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • No restriction stated
 
Tipranavir
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Provider notes

  • NMUH:
    • To be prescribed as per BHIVA Guidelines by the HIV team only
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Non-formulary
 
05.03.01  Non-nucleoside reverse transcriptase inhibitors to top
Efavirenz
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • No restriction stated
 
Etravirine
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Provider notes

  • NMUH:
    • To be prescribed as per BHIVA Guidelines by the HIV team only
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Non-formulary
 
Nevirapine
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • For TB/HIV clinic & Womens Health
 
05.03.01  Other antiretrovirals
Dolutegravir
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Non-formulary
 
Link  NHSE B06/P/a: Dolutegravir for treatment of HIV1 in adults and adolescents
Dolutegravir + Abacavir + Lamivudine
(Triumeq®)
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Approved for HIV in line with NHSE Commissioning Policy B06/P/a.

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NHSE B06/P/a: Dolutegravir for treatment of HIV1 in adults and adolescents
Dolutegravir + Rilpivirine
(Juluca®)
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Approved for HIV in line with NHSE Commissioning Policy 200210P.

Provider notes

  • NMUH:
    • Restricted to HIV team ONLY
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Link  NHSE 200210P: Dolutegravir-rilpivirine for treating HIV-1 in adults
Enfuvirtide
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Provider notes

  • NMUH:
    • To be used in accordance with the London HIV consortium BHIVA guidelines
    • For HIV team only
    • Patients currently benefiting from enfuvirtide in their combination therapy should continue to receive enfuvirtide without interruption. Current benefit is defined as patients whose viral load is either undetectable or remaining below their pre-enfuvirtide baseline level. Patients whose current viral load has substantially rebounded or returned to their baseline level when their first used enfuvirtide and who have a strong CD4 count, are likely to have developed or be developing resistance to enfuvirtide. Enfuvirtide is also unlikely to be having antiretroviral activity, and these patients should consider stopping the enfuvirtide in their combination, with close monitoring BHIVA Guidelines - Treatment of HIV-1 infected adults with antiretroviral therapy
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Non-formulary
 
Maraviroc
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Non-formulary
 
Raltegravir
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Restricted for use in accordance with RNOH Sharps Policy and Inoculation Management (see policy)
  • UCLH:
  • WH:
    • For TB / HIV clinic and post-exposure prophylaxis
 
Link  RNOH: Sharps Policy and Inoculation Management
05.03.02  Herpesvirus infections
05.03.02.01  Herpes simplex and varicella-zoster infection
Aciclovir
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • No restriction stated
 
Famciclovir
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • For Microbiology use only
 
Valaciclovir
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Formulary
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Follow virology/microbiology guidelines
  • RNOH:
    • Following virology/microbiology approval
  • UCLH:
  • WH:
    • No restriction stated
 
05.03.02.02  Cytomegalovirus infection
Cidofovir infusion
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Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • HIV/Virology approval required
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Foscarnet sodium IV
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Provider notes

  • NMUH:
    • Restricted for HIV patients use only.
  • RFL:
    • Restricted to HIV; Transplant patients; Haematology; Oncology
    • Virology approval required for all other indications
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Ganciclovir IV
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Restricted to HIV; Transplants; Other immunosuppressed patients
    • Virology approval required for all other indications
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Check with Microbiology
 
Valganciclovir
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Restricted to HIV; Transplants; Other immunosuppressed patients
    • Virology approval required for all other indications
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Restricted to Microbiology
 
Ganciclovir oral
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Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Restricted to Microbiology
 
05.03.03  Viral hepatitis to top
05.03.03.01  Chronic hepatitis B
Adefovir Dipivoxil
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Provider notes

  • NMUH:
    • This medicine has a positive NICE Technology Appraisal BUT IS NOT LISTED IN THE TRUST FORMULARY AS AN ALTERNATIVE NICE APPROVED MEDICINE IS USED.
  • RFL:
    • Restricted to Hepatology/Virology
    • As per NICE guidance
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NICE TA96: Hep B - adefovir dipivoxil and pegylated interferon alpha-2a
Entecavir
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Provider notes

  • NMUH:
    • Positive NICE TA This medicine has a positive NICE Technology Appraisal and is listed in the Trust Medicines Formulary when used in line with NICE recommendations and/or Local Trust Guidelines.
    • See link below
  • RFL:
    • See NICE TA for eligibility criteria
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NICE TA153: Hepatitis B (chronic) - etecavir
05.03.03.02  Chronic hepatitis C
Dasabuvir
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Provider notes

  • NMUH:
    • To be prescribed by Consultants Andrew Millar, Dimitra Doufexi and Jonathan Ainsworth only for Hepatitis C
    • Check MHRA Drug Safety Updates
  • RFL:
    • For use by Hepatology in the treatment of Hepatitis C in line with NICE guidance
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Link  NICE TA365: Ombitasvir–paritaprevir–ritonavir with or without dasabuvir for treating chronic hepatitis C
Elbasvir + Grazoprevir
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Provider notes

  • NMUH:
    • This medicine has a positive NICE Technology Appraisal and is listed in the Trust Medicines Formulary when used in line with NICE recommendations and/or Local Trust Guidelines.
    • See links below
    • To be prescribed by Consultants Andrew Millar, Dimitra Doufexi and Jonathan Ainsworth ONLY for Hepatitis C.
  • RFL:
    • Approved for use by Hepatology in the treatment of Hepatitis C in line with NICE guidance
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NICE TA413: Elbasvir–grazoprevir for treating chronic hepatitis C
Glecaprevir + Pibrentasvir
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Formulary
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Provider notes

  • NMUH:
    • This medicines has a positive NICE TA and will be included in the formulary once NMUH is able to provide this medicine VAT free.
  • RFL:
    • Approved for use by Hepatology for the treatment of Hepatitis C in line with NICE guidance
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NICE TA499: Glecaprevir–pibrentasvir for treating chronic hepatitis C
Ledipasvir + Sofosbuvir
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Provider notes

  • NMUH:
    • This medicine has a positive NICE Technology Appraisal and is listed in the Trust Medicines Formulary when used in line with NICE recommendations and/or Local Trust Guidelines.
    • To be prescribed by Consultants Andrew Millar, Dimitra Doufexi and Jonathan Ainsworth ONLY for Hepatitis C.
    • Check MHRA Drug Safety Updates
  • RFL:
    • Approved for use by Hepatology in the treatment of Hepatitis C in line with NICE guidance
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NICE TA363: Ledipasvir–sofosbuvir for treating chronic hepatitis C
Ombitasvir + paritaprevir + ritonavir
(Viekirax®)
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Provider notes

  • NMUH:
    • This medicine has a positive NICE Technology Appraisal and is listed in the Trust Medicines Formulary when used in line with NICE recommendations and/or Local Trust Guidelines.
    • To be prescribed by Consultants Andrew Millar, Dimitra Doufexi nd Jonathan Ainsworth ONLY for Hepatitis C.
    • Check MHRA Drug Safety Updates
  • RFL:
    • Approved for use by Hepatology in the treatment of Hepatitis C in line with NICE guidance
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NICE TA365: Ombitasvir–paritaprevir–ritonavir with or without dasabuvir for treating chronic hepatitis C
Ribavirin
(Hepatitis)
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NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Approved for hepatitis B (see NICE TA for eligibility criteria) and chronic hepatitis E viraemia in immunosuppressed individuals (JFC June 2016)

Provider notes

  • NMUH:
    • This medicine has a positive NICE Technology Appraisal and is listed in the Trust Medicines Formulary when used in line with NICE recommendations and/or Local Trust Guidelines
    • See links below
    • Ribavirin is listed on this formulary for treatment of chronic hepatitis C and for immunosuppressed individuals with chronic hepatitis E viraemia
    • Ribavirin should only be prescribed by Hepatologists
  • RFL:
    • Virology/Microbiology/ID approval only.
    • Hepatology use approved for the treatment of Hepatitis C in line with NICE guidance and Hepatitis E
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • As per JFC and NICE TA
    • Ribavirin should only be prescribed by Hepatologists
 
Link  NICE TA106: Hepatitis C - peginterferon alfa and ribavirin
Link  NICE TA200: Hepatitis C - peginterferon alfa and ribavirin
Link  NICE TA300: Hepatitis C - peginterferon alfa and ribavirin in children and young people
Link  NICE TA75: Hepatitis C - pegylated interferons, ribavirin and alfa interferon
Sofosbuvir
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Provider notes

  • NMUH:
    • This medicine has a positive NICE Technology Appraisal and is listed in the Trust Medicines Formulary when used in line with NICE recommendations and/or Local Trust Guidelines.
    • To be prescribed by Consultants Andrew Millar, Dimitra Doufexi and Jonathan Ainsworth ONLY for Hepatitis C.
    • Check MHRA Drug Safety Updates
  • RFL:
    • Approved for use by Hepatology in the treatment of Hepatitis C in line with NICE guidance
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NICE TA330: Sofosbuvir for treating chronic hepatitis C
Sofosbuvir + Velpatasvir
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Provider notes

  • NMUH:
    • This medicine has a positive NICE Technology Appraisal and is listed in the Trust Medicines Formulary when used in line with NICE recommendations and/or Local Trust Guidelines.
    • To be prescribed by Consultants Andrew Millar, Dimitra Doufexi and Jonathan Ainsworth ONLY for Hepatitis C.
    • Check MHRA Drug Safety Updates
  • RFL:
    • Approved for use by Hepatology in the treatment of Hepatitis C in line with NICE guidance
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NICE TA430: Sofosbuvir–velpatasvir for treating chronic hepatitis C
Sofosbuvir + Velpatasvir + Voxilaprevir
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Provider notes

  • NMUH:
    • This medicines has a positive NICE TA and will be included in the formulary once NMUH is able to provide this medicine VAT free.
  • RFL:
    • Approved for use by Hepatology for the treatment of Hepatitis C in line with NICE guidance
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Link  NICE TA507: Sofosbuvir–velpatasvir–voxilaprevir for treating chronic hepatitis C
05.03.04  Influenza
Oseltamivir
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Provider notes

  • NMUH:
    • This medicine has a positive NICE Technology Appraisal and is listed in the Trust Medicines Formulary when used in line with NICE recommendations and/or Local Trust Guidelines.
    • Indicated for the prophylaxis and treatment of influenza, as per NICE guidelines
  • RFL:
    • Virology/Microbiology/ID approval only
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NICE TA158 (amantadine NOT recommended): Oseltamivir, amantadine (review) and zanamivir for the prophylaxis of influenza
Link  NICE TA168: Amantadine, oseltamivir and zanamivir for the treatment of influenza
Zanamivir inhalation
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Provider notes

  • NMUH:
    • This medicine has a positive NICE Technology Appraisal and is listed in the Trust Medicines Formulary when used in line with NICE recommendations and/or Local Trust Guidelines.
    • Indicated for the prophylaxis and treatment of influenza, as per NICE guidelines
  • RFL:
    • Virology/Microbiology/ID approval only
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • Microbiology approval only
 
Link  NICE TA158 (amantadine NOT recommended): Oseltamivir, amantadine (review) and zanamivir for the prophylaxis of influenza
Link  NICE TA168: Amantadine, oseltamivir and zanamivir for the treatment of influenza
Amantadine
(Influenza)
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NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Virology/Microbiology/ID approval only
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • Microbiologist approval only
 
Link  NICE TA158 (amantadine NOT recommended): Oseltamivir, amantadine (review) and zanamivir for the prophylaxis of influenza
Link  NICE TA168 (amantadine NOT recommended): Amantadine, oseltamivir and zanamivir for the treatment of influenza
Zanamivir injection
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Approved for for treatment of complicated and potentially life-threatening influenza A or B virus infection in patient's whose influenza virus is known or suspected to be resistant to anti-influenza medicinal products other than zanamivir, and/or other anti-viral medicinal products for treatment of influenza, including inhaled zanamivir, are not suitable for the individual patient (JFC September 2019).

Provider notes

  • NMUH:
    • Microbiology approval only
  • RFL:
    • Virology/Microbiology/ID approval only
  • RNOH:
    • Requires Microbiology approval
  • UCLH:
  • WH:
    • Microbiology approval only
 
05.03.05  Respiratory syncytial virus
Palivizumab
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Restricted to paediatrics and neonates
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
05.04  Antiprotozoal drugs to top
Metronidazole
(Antiprotozoal )
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NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • Non-formulary  
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • No restriction stated
 
05.04.01  Antimalarials
Artesunate
(Antimalarial)
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Approved for severe falciparum malaria (November 2015) 

Provider notes

  • NMUH:
    • To be used on the recommendation of the Infectious Diseases Team or Microbiology according to the NMUHT malaria guidelines.
    • See Trust guideline via intranet
    • Available from ‘special-order’ manufacturers or specialist importing companies
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  WH: Malaria Investigation and Treatment Guideline for Adults
05.04.01  Treatment of malaria
05.04.01  Falciparum malaria (treatment)
05.04.01  Benign malarias (treatment)
05.04.01  Prophylaxis against malaria to top
05.04.01  Specific recommendations
05.04.01  Artemether with lumefabtrine
Artemether + Lumefantrine
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Provider notes

  • NMUH:
    • To be used as per the NMUHT Malaria Guidelines, sccess via intranet
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • First line for uncomplicated falciparum malaria, chloroquine-resistant non-falciparum malaria, and PO step down from IV artesunate
    • See link below
 
Link  WH: Malaria Investigation and Treatment Guideline for Adults
05.04.01  Chloroquine
Chloroquine
(Antimalarial)
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Formulary
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NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • To be used as per the NMUHT Malaria Guidelines, access via Trust intranet
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
05.04.01  Mefloquine
Mefloquine
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
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Provider notes

  • NMUH:
    • Restricted to HIV patients only
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
05.04.01  Primaquine to top
Primaquine
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed
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Provider notes

  • NMUH:
    • To be used as per NMUH Malaria Guidelines, access via Trust intranet
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
05.04.01  Proguanil
Atovaquone + Proguanil
(Malaria)
View adult BNF View SPC online View childrens BNF
Formulary
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Provider notes

  • NMUH:
    • To be used as per the NMUHT Malaria Guidelines, access via intranet
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Proguanil
View adult BNF View SPC online View childrens BNF
Formulary
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Provider notes

  • NMUH:
    • To be used as per the NMUH malaria guidelines, access via Trust intranet
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
05.04.01  Pyrimethamine
Pyrimethamine
View adult BNF View SPC online View childrens BNF
Formulary
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • For Microbiology use only
 
Pyrimethamine + Sulfadoxine
View adult BNF View SPC online View childrens BNF
Formulary
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Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
05.04.01  Quinine
Quinine
(Antimalarial)
View adult BNF View SPC online View childrens BNF
Protected Drug Protected
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NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • See Trust guideline on intranet for further information
  • RFL:
    • No restriction stated
  • RNOH:
    • Includes sulphate and bisulphate preparations
  • UCLH:
  • WH:
    • Qunine can accumulate with long term use and cause toxicity

 

 
Quinine dihydrochloride
(Antimalarial)
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed
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NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • See Trust guideline on intranet for further information
  • RFL:
    • No restriction stated
  • RNOH:
    • TBC
  • UCLH:
  • WH:
    • No restriction stated
 
05.04.01  Tetracyclines
Doxycycline
(Antimalarial)
View adult BNF View SPC online View childrens BNF
Formulary
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NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • See Trust guideline on intranet for further information
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
05.04.02  Amoebicides to top
Diloxanide
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
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Provider notes

  • NMUH:
    • Non-formulary  
  • RFL:
    • Microbiology/ID consultant approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Tinidazole
(Antiprotozoal )
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
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NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • Non-formulary  
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
05.04.03  Trichomonacides
05.04.04  Antigiardial drugs
Mepacrine Hydrochloride
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed
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Provider notes

  • NMUH:
    • Restricted to Rheumatology Consultants
  • RFL:
    • Restricted to Rheumatology, Dermatology, Microbiology or Infectious Diseases consultants
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
05.04.05  Leishmaniacides
05.04.06  Trypanocides
05.04.07  Drugs for toxoplasmosis to top
Sulfadiazine
View adult BNF View SPC online View childrens BNF
Formulary
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
05.04.08  Drugs for pneumocystis pneumonia
Atovaquone
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
GP - Red
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • For Microbiology use only
 
Pentamidine isetionate
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
GP - Red
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • For Microbiology use only
 
05.04.08  Treatment
05.04.08  Prophylaxis
05.05  Anthelmintics
05.05.01  Drugs for threadworms to top
Mebendazole
View adult BNF View SPC online View childrens BNF
Formulary
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • No restriction stated
 
Albendazole
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed
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Provider notes

  • NMUH:
    • For use for named patients only
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
05.05.02  Ascaricides
05.05.03  Drugs for tapeworm infections
05.05.03  Taenicides
05.05.03  Hydatid disease
05.05.04  Drugs for hookworms to top
05.05.05  Schistosomicides
Praziquantel
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
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Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
05.05.06  Filaricides
05.05.07  Drugs for cutaneous larva migrans
Ivermectin tablets
(Anthelmintics)
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed
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Provider notes

  • NMUH:
    • 3mg tablets available from 'special order'
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
05.05.08  Drugs for strongyloidiasis
05.06  Unlicensed Medicines / Significant off-label use to top
Taurolodine and Citrate 4%
(TauroLock®)
View childrens BNF
Restricted Drug Restricted
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Approved for recurrent catheter-releated bloodstream infections. Restricted to patients who have had ≥ 2 CRBI in 6 months or ≥ 3 CRBI in 12 months  (August 2015)

 

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • As above
 
Nitazoxanide
View childrens BNF
Unlicensed Drug Unlicensed
High Cost Medicine
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Nitazoxanide for chronic resistant norovirus infection in PID patients – Approved for prescribing by Immunology only (JFC August 2013)

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • For chronic resistant norovirus infection in PID patients
    • Restricted to immunology only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Pristinamycin tablets
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed
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Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • Microbiologist approval only for the treatment of joint infection
    • This medicine is not licensed in the UK
    • 500mg tablets
  • UCLH:
  • WH:
    • Non-formulary
 
Spectinomycin injection
View childrens BNF
Unlicensed Drug Unlicensed
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Provider notes

  • NMUH:
    • Restricted to Consultants in GU Medicine only
    • Should only be used in penicillin-allergic patients
    • Available from ‘special-order’ manufacturers or specialist importing companies
  • RFL:
    • Restricted to TB
    • All other indications require Microbiology / ID or thoracics approval required
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Microbiology approval required
 
Spiramycin
(Toxoplasmosis)
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed
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Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Restricted to ID/Microbiology only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Advice of Microbiology only
 
Streptomycin sulphate
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed
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Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Restricted to TB
    • All other indications require Microbiology / ID or thoracics approval required
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Streptomycin injection available after microbiology approval
 
Triclabendazole
(Human Fascioliasis)
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed
GP - Red
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Approved for Human Fascioliasis Infection (JFC April 2019)

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • As per indication above
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • As above
 
 ....
 Non Formulary Items
Aciclovir lauriad (Sitavig)

View adult BNF View SPC online View childrens BNF
Non Formulary
Amphotericin lipid complex infusion
(Abelcet®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
Ampicillin

View adult BNF View SPC online View childrens BNF
Non Formulary
Aztreonam nebuliser solution
(Cayston®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
Cefaclor

View adult BNF View SPC online View childrens BNF
Non Formulary
Cefadroxil

View adult BNF View SPC online View childrens BNF
Non Formulary
Cefradine

View adult BNF View SPC online View childrens BNF
Non Formulary
Ceftaroline

View adult BNF View SPC online View childrens BNF
Non Formulary
Ceftobiprole

View adult BNF View SPC online View childrens BNF
Non Formulary
Cefuroxime Axetil

View adult BNF View SPC online View childrens BNF
Non Formulary
Chloroquine + Proguanil

View adult BNF View SPC online View childrens BNF
Non Formulary
Clarithromycin modified release

View adult BNF View SPC online View childrens BNF
Non Formulary
Co-Fluampicil
(Ampicillin + Flucloxacillin)

View adult BNF View SPC online View childrens BNF
Non Formulary
Colistimethate inhaler
(Colobreathe®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
Link  NICE TA276: Cystic fibrosis (pseudomonas lung infection) - colistimethate sodium and tobramycin
Collatamp EG Sponge

View adult BNF View SPC online View childrens BNF
Non Formulary
Black

Not approved for osteomyelitis (JFC May 2016)

Doravirine + Lamivudine + Tenofovir disoproxil
(Delstrigo®)

View adult BNF View SPC online View childrens BNF
Non Formulary
GP - Red

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
Link  NHSE 190137P: Doravirine for the treatment of HIV-1 in adults
Doravirine tabs
(Pifeltro®)

View adult BNF View SPC online View childrens BNF
Non Formulary
GP - Red

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
Link  NHSE 190137P: Doravirine for the treatment of HIV-1 in adults
Inosine Pranobex

View adult BNF View SPC online View childrens BNF
Non Formulary
Ketoconazole tablets
(Antifungal)

View adult BNF View SPC online View childrens BNF
Non Formulary

NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

License withdrawn for this indication

Letermovir tabs

View adult BNF View SPC online View childrens BNF
Non Formulary
GP - Red

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
    • Non-formulary
  • WH:
    • Non-formulary
Link  NICE TA591: Letermovir for preventing cytomegalovirus disease after a stem cell transplant
Levofloxacin nebuliser
(Quinsair®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
Link  NCL JFC: Safe prescribing of fluoroquinolones Position Statement
Micafungin

View adult BNF View SPC online View childrens BNF
Non Formulary
GP - Red
High Cost Medicine
Nalidixic Acid

View adult BNF View SPC online View childrens BNF
Non Formulary
Netilmicin
(Netillin®)

View adult BNF View SPC online View childrens BNF
Non Formulary
Niclosamide

View adult BNF View SPC online View childrens BNF
Non Formulary
Norfloxacin

View adult BNF View SPC online View childrens BNF
Non Formulary
Link  NCL JFC: Safe prescribing of fluoroquinolones Position Statement
Oritavancin (Orbactiv®)

View adult BNF View SPC online View childrens BNF
Non Formulary
Piperaquine + Artenimol
(Eurartesim®)

View adult BNF View SPC online View childrens BNF
Non Formulary
Piperazine

View adult BNF View SPC online View childrens BNF
Non Formulary
Quinupristin and dalfopristin
(Synercid®)

View adult BNF View SPC online View childrens BNF
Non Formulary
Remdesivir infusion

View adult BNF View SPC online View childrens BNF
Non Formulary
GP - Red

Provider notes

  • NMUH:
    • Non-formulary 
  • RFL:
    • Non-formulary 
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary 
Sinecatechins (Veregen)

View adult BNF View SPC online View childrens BNF
Non Formulary
Sodium Stibogluconate

View adult BNF View SPC online View childrens BNF
Non Formulary
SPL7013 (VivaGel®)

View adult BNF View SPC online View childrens BNF
Non Formulary
Tedizolid

View adult BNF View SPC online View childrens BNF
Non Formulary
Telavancin

View adult BNF View SPC online View childrens BNF
Non Formulary
Telbivudine

View adult BNF View SPC online View childrens BNF
Non Formulary
GP - Red
Link  NICE TA154 (not recommended): Telbivudine for the treatment of chronic hepatitis B
Telithromycin (Ketek®)

View adult BNF View SPC online View childrens BNF
Non Formulary
TIABENDAZOLE 500mg tabs

View adult BNF View SPC online View childrens BNF
Non Formulary
Ticarcillin + Clavulanic acid

View adult BNF View SPC online View childrens BNF
Non Formulary
Tobramycin inhaler
(Cystic fibrosis)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
Link  NICE TA276: Cystic fibrosis (pseudomonas lung infection) - colistimethate sodium and tobramycin
Tobramycin nebuliser
(Cystic fibrosis)

View adult BNF View SPC online View childrens BNF
Non Formulary

NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Tobramycin nebuliser
(Non-CF bronchiectasis)

View adult BNF View SPC online View childrens BNF
Non Formulary
Black
High Cost Medicine

NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Not approved for non-CF bronchiectasis (April 2017)

  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
Homecare
Homecare

Traffic Light Status Information

Status Description

GP - 1st

Medicines suitable for first-line use within primary care.

Can be initiated within primary care within their licensed indication, in accordance with nationally recognised formularies, for example the BNF, BNF for Children, Medicines for Children or Palliative Care Formulary. Primary care prescribers take full responsibility for prescribing. 

  

GP - 2nd

Medicines suitable for second-line use within primary care.

Can be initiated within primary care within their licensed indication, in accordance with nationally recognised formularies, for example the BNF, BNF for Children, Medicines for Children or Palliative Care Formulary. Primary care prescribers take full responsibility for prescribing. 

  

GP - Amber

Medicines that should be initiated by a specialist. Prescribing can be transferred to primary care once the patient has been stabilised.  

Shared care: For drugs with regular, ongoing need for monitoring and/or assessment of efficacy or toxicity. Prior agreement must be obtained by the specialist from the primary care provider before prescribing responsibility is transferred. The shared care protocol must have been agreed by the relevant secondary care trust Drugs and Therapeutics Committee(s) (DTC) and approved by the North Central London JFC.

Fact sheet: For drugs with some concerns surrounding safety or efficacy but do not require regular monitoring and/or monitoring of effectiveness/toxicity.

  

GP - Red

Medicines which should normally be prescribed by specialists only (hospital only).

For patients already receiving prescriptions in primary care - continue. No new patients to receive prescriptions in primary care.

See link for the complete NCL Red List https://www.ncl-mon.nhs.uk/wp-content/uploads/2017/08/ncl_red_list.pdf

  

GP - Grey

Medicines on hospital formularies which have not been reviewed for suitability in primary care.  

Black

Medicines not recommended for routine use in primary or secondary care.

Medicines, which the North Central London JFC has actively reviewed and does not recommend for use at present due to limited clinical and/or cost effective data.

  

netFormulary