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 Formulary Chapter 5: Infections - Full Chapter
Notes:

Prescribing of systemic antimicrobials is 'protected'. All prescribing MUST be in accordance with the Trust Antimicrobial Policy and in conjunction with local antimicrobial guideline:

 Details...
05.01  Antibacterial drugs
05.01  Table 1. Summary of antibacterial therapy
05.01  Table 2. Summary of antibacterial prophylaxis
05.01.01  Penicillins
05.01.01.01  Benzylpenicillin and phenoxymethylpenicillin to top
Benzylpenicillin
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Formulary

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • No restriction stated
 
   
Phenoxymethylpenicillin
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Formulary

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • No restriction stated
 
   
Benzathine benzylpenicillin
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Unlicensed Drug Unlicensed

Provider notes

  • NMUH:
    • Used in the treatment of early syphilis and late latent syphilis
    • Benzathine Benzylpenicillin 2.4 mega unit injection, available from ‘special-order’ manufacturers or specialist importing companies
  • RFL:
    • Microbiology/ID approval only
  • RNOH approvals
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
   
Procaine Penicillin G Injection
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Unlicensed Drug Unlicensed

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Restricted to Micro/ID recommendation only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
   
05.01.01.02  Penicillinase-resistant penicillins
Flucloxacillin
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Formulary

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • No restriction stated
 
   
Temocillin
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Restricted Drug Restricted

Store in a refrigerator

Provider notes

  • NMUH:
    • Consultant Microbiologist recommendation only
  • RFL:
    • See Microguide for agreed indications
    • Microbiology/ID approval required for all other indications
  • RNOH:
    • Approved for ESBL infections. Restricted to Microbiology recommendation only
  • UCLH:
  • WH:
    • Microbiology approval required
 
   
05.01.01.03  Broad-spectrum penicillins
Amoxicillin
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Formulary

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • Oral suspension available as 125 mg/5mL and 250 mg/5mL
  • UCLH:
  • WH:
    • No restriction stated
 
   
Co-Amoxiclav
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Formulary

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • Oral suspension available as 125/31.25 mg/5mL and 250/62.5 mg/5mL
  • UCLH:
  • WH:
    • No restriction stated
 
   
05.01.01.04  Antipseudomonal penicillins
Piperacillin + Tazobactam
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • As per RFL microbiology guidelines
    • ITU - microbiology approval required within 48 hours for other uses
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Check with microbiology
 
   
05.01.01.05  Mecillinams
Pivmecillinam
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Restricted Drug Restricted

Approved for uncomplicated UTI linked to suspected/proven ESBL (JFC November 2015) 

Provider notes

  • NMUH:
    • Restricted. Microbiology advice only
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • Restricted for suspected or proven ESBL only
  • UCLH:
  • WH:
    • No restriction stated
 
   
05.01.02  Cephalosporins, carbapenems and other beta-lactums to top
05.01.02  Cephalosporins
05.01.02  Other beta-lactam antibiotics
05.01.02.01  Cephalosporins
Cefalexin
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Formulary

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • See Microguide for approved indications
    • Microbiology/ID approval required for all other indications
  • RNOH:
    • Oral suspension available as 250 mg/5mL
  • UCLH:
  • WH:
    • No restriction stated
 
   
Cefazolin
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Formulary

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Approved for surgical prophylaxis
    • Microbiology/ID approval required for all other indications
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
   
Cefixime
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Restricted to Consultants in GU Medicine.
  • RFL:
    • Restricted to GUM
    • Microbiology/ID approval required for all other indications
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
   
Cefotaxime
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Formulary

Provider notes

  • NMUH:
    • Restricted to Microbiology approval only
  • RFL:
    • See Microguide for approved indications. Approved for Neonatal unit
    • Microbiology/ID approval required for all other indications
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Restricted to Paediatrics and Neonatal use only
 
   
Ceftazidime
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Restricted to Microbiology approval only
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • For restricted indications as per Trust guidelines or Microbiology advice
 
   
Ceftazidime + Avibactam
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Restricted Drug Restricted
GP - Red

Approved for the treatment of infections caused by non-MBL carbapenemase-producing aerobic Gram-negative organisms, that have proven susceptibly to ceftazidime-avibactam and where the only alternative active agents, if any, are limited to colistin, tigecycline and fosfomycin, which cannot be used due to resistance or intolerance - Microbiology recommendation only (JFC August 2017)

Provider notes

  • NMUH:
    • Microbiology approval only
  • RFL:
    • Consultant Microbiology/ID approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Restricted antibiotics. Microbiology approval only
 
   
Ceftolozane + tazobactam
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Restricted Drug Restricted
GP - Red

Approved for multi-resistant Gram-negative organisms that have proven susceptibly to ceftolozane-tazobactam and where the only alternative active agents, if any, are limited to colistin, tigecycline and fosfomycin (JFC September 2016)

Provider notes

  • NMUH:
    • Microbiology recommendation ONLY
  • RFL:
    • Consultant Microbiology/ID approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Restricted antibiotics. Microbiology approval only
 
   
Ceftriaxone
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Restricted to use in paediatrics for sepsis and meningitis
  • RFL:
    • See Microguide for agreed indications
    • Microbiology/ID approval required for all other indications
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • For restricted indications as per Trust guidelines or Microbiology advice
 
   
Cefuroxime
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Restricted to Microbiology approval only
    • Injection is formulary
    • Tablets are non-formulary
  • RFL:
    • See Microguide for approved indications
    • Microbiology/ID approval required for all other indications
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Non-formulary
 
   
05.01.02.02  Carbapenems
Ertapenem
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Microbiology approval only
  • RFL:
    • Microbiology approval only (except ITU, microbiology approval required within 48 hours)
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • Restricted antibiotic - Microbiology approval only
 
   
Imipenem + Cilastatin
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Microbiology approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
   
Meropenem
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Microbiology approval only
  • RFL:
    • Restricted to Neutropenic sepsis (penicillin allergy) and ITU (microbiology approval required within 48 hours)
    • Microbiology approval for all other indications
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Microbiology approval only
 
   
05.01.02.03  Other beta-lactams antibiotics to top
Aztreonam
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Consultant Microbiologist recommendation only
  • RFL:
    • Microbiology approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
   
05.01.03  Tetracyclines
Demeclocycline
(Antibiotic)
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Restricted Drug Restricted

NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
    • ???
  • WH:
    • Microbiology approval only
 
   
Doxycycline
(Antibiotic)
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Formulary

NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Oral: See Microguide for approved indications
    • IV: Seek Microbiology, ID or Pharmacy advice before prescribing
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • No restriction stated
 
   
Lymecycline
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Reserved for Dermatology use only
 
   
Minocycline
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Restricted to Dermatology and Rheumatology for calcinosis
    • Microbiology approval required for all other indications
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Check with Microbiology
 
   
Minocycline modified release
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • for Dermatology use ONLY
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • ???Reserved for Dermatology use only
 
   
Oxytetracycline
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • For Microbiology use only
 
   
Tetracycline
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Formulary

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Reserved for H.pylori treatment in penicillin allergy
 
   
05.01.03  Tigecycline
Tigecycline
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Consultant Microbiologist recommendation only
  • RFL:
    • Microbiology approval only
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • Microbiology approval only
 
   
05.01.04  Aminoglycosides
Amikacin injection
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Restricted to Microbiology approval only
  • RFL:
    • Refer to amikacin prescribing guidelines in Microguide
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Microbiology approval only
 
   
Gentamicin injection
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Formulary

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Refer to gentamicin prescribing guidelines in Microguide
  • RNOH:
    • Different brands of gentamicin 80mg in 2mL vials are stocked at RNOH
    • The Amdipharm, Hospira and Sanofi brands are licensed for administration intramuscularly (IM) and intravenously (IV) and will be kept as stock in all ward areas.
    • The Wockhardt brand is licensed for intravenous route (IV) only and will be stocked in Theatres only. This formulation must not be administered intramuscularly.
  • UCLH:
  • WH:
    • No restriction stated
 
   
Neomycin tablets
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Non-formulary  
  • RFL:
    • Restricted to Colorectal Surgery
    • Microbiology/ID approval required for all other indications
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
   
Tobramycin injection
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Microbiologist approval only
  • RFL:
    • Microbiologist approval only
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • Non-formulary
 
   
05.01.05  Macrolides
Azithromycin tabs/caps/suspension
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Refer to Microguide for agreed indications, all other indications require microbiology approval
    • Used for prophylaxis and treatment of Mycobacterium avium intracellulare in HIV
  • RNOH:
    • Oral suspension available as 200 mg/5mL
  • UCLH:
  • WH:
    • Suspension is reserved for Paediatric and Neonatal use only
 
   
Clarithromycin
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • Microbiologist approval only
    • Oral suspension available as 250 mg/5mL
  • UCLH:
  • WH:
    • No restriction stated
 
   
Erythromycin
(Anti-infective)
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Formulary

NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • Injection is reserved for the use of Paediatrics only
  • RFL:
    • No restriction stated
  • RNOH:
    • Oral suspension available as 125 mg/5mL and 250 mg/5mL
  • UCLH:
  • WH:
    • Restricted to Maternity use or as prokinetic
 
   
05.01.06  Clindamycin to top
Clindamycin
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • As per RFL policy on microguide
    • Microbiology approval required for all other indications
    • Used for prophylaxis and treatment of Mycobacterium avium intracellulare in HIV
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Microbiology approval only
 
   
05.01.07  Some other antibacterials
Dalbavancin infusion
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Restricted Drug Restricted

Approved if recommended by Microbiology for skin and soft tissue infections in patients only if (JFC April 2017):

  • unable to receive oral therapy and
  • available treatment pathways for repeated IV antibiotics are unsuitable e.g. chaotic lifestyle, immobility, poor venous access

Provider notes

  • NMUH:
    • On microbiology recommendation only
  • RFL:
    • Restricted to Microbiology Consultant only
  • RNOH:
    • Non-formulary
  • UCLH:
    • Skin and soft tissue infections in patients unable to receive oral therapy- Restricted to Microbiology recommendation (JFC April 2017)
  • WH:
    • As above (restricted to Microbiology)
 
   
Rifaximin (Xifaxanta®)
(SIBO)
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Restricted Drug Restricted
GP - Red

Approved for small intestine bacterial overgrowth (SIBO) in patients with systemic sclerosis (SSc) only (JFC June 2019)

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Approved for use in the treatment of small intestinal bacterial overgrowth (SIBO) in systemic sclerosis (SSc) patients only
  • RNOH:
    • Non-formulary
  • UCLH:
    • Non-formulary
  • WH:
    • Approved for use in the treatment of small intestinal bacterial overgrowth (SIBO) in systemic sclerosis (SSc) patients only
 
   
05.01.07  Chloramphenicol
Chloramphenicol
(Systemic)
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Chloramphenicol capsules are non-formulary
    • To be used as per the Trust guidelines for Management of Acute Bacterial Meningitis 
  • RFL:
    • As per agreed indications on microguide
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Microbiology approval only
 
   
05.01.07  Fosfomycin
Fosfomycin oral sachets
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Restricted Drug Restricted

Approved for prescribing in primary and secondary care for symptomatic UTI sensitive to fosfomycin, where patients are unable to receive, or the organism is resistant to, first-line antibiotics (July 2015)

Provider notes

  • NMUH:
    • Consultant Microbiology approval only
  • RFL:
    • See Microguide for approved indications
    • Microbiology/ID approval required for all other indications
  • RNOH:
    • Microbiology approval only
  • UCLH:
  • WH:
    • Microbiology approval only
 
   
Fosfomycin intravenous
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Restricted Drug Restricted

Microbiology approval only for treatment of infections, or suspected infections, caused by multi-drug resistant Gram-negative organisms, including ESBLs (JFC August 2016)

Provider notes

  • NMUH:
    • Should only be prescribed following advice from a Consultant Microbiologist
  • RFL:
    • Consultant Microbiology/ID approval only
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Microbiology approval only
 
   
05.01.07  Fusidic acid
Sodium fusidate
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Microbiology approval only
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Microbiology approval only
 
   
05.01.07  Vancomycin and teicoplanin to top
Teicoplanin
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Microbiology approval only
  • RFL:
    • See microbiology guidelines for agreed indications
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Restricted to OPAT and theatres
 
   
Vancomycin intravenous
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Microbiology approval only
  • RFL:
    • Refer to vancomycin prescribing guidelines in Microguide
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Check with Microbiology
 
   
Vancomycin oral
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Microbiology approval only
  • RFL:
    • Injection used orally: Refer to Microguide for C. difficile treatment (injection is licensed for oral use and should be used for inpatients) 
    • Capsules: Outpatient and discharge prescribing only
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Microbiology approval only
 
   
05.01.07  Daptomycin
Daptomycin
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Restricted Drug Restricted

Store in a refrigerator

Provider notes

  • NMUH:
    • Consultant Microbiologist approval only
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • Microbiology approval only
  • UCLH:
  • WH:
    • Microbiology approval only
 
   
05.01.07  Linezolid
Linezolid
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Microbiology approval only
  • RFL:
    • Microbiology/ID approval required
  • RNOH:
    • Microbiology approval only
  • UCLH:
  • WH:
    • Microbiology approval only
 
   
05.01.07  Quinupristin and dalfopristin
05.01.07  Polymyxins
Colistimethate for nebulisation
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Restricted Drug Restricted
High Cost Medicine

Provider notes

  • NMUH:
    • Microbiology recommendation only
  • RFL:
    • Consultant Microbiology/ID approval only
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • Check with Microbiology
 
   
Colistimethate injection
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Microbiology recommendation only
  • RFL:
    • Consultant Microbiology/ID approval only
  •  RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • Check with Microbiology
 
   
05.01.07  Rifaximin to top
Rifaximin (Targaxan®)
(Encephalopathy)
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Restricted Drug Restricted
GP - Amber

Provider notes

  • NMUH:
    • This medicine has a positive NICE Technology Appraisal and is listed in the Trust Medicines Formulary when used in line with NICE recommendations and/or Local Trust Guidelines.
    • See links below
    • To be prescribed by the Gastroenterology team
  • RFL:
    • To be prescribed by the gastro/hepatology teams for use in the treatment of hepatic encephalopathy  - see local policy
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Gastroenterology approval only - hepatic encephalopathy.
 
Link  NCL JFC: Shared Care Guideline Rifaximin (Targaxan®) Treatment of hepatic encephalopathy
Link  NICE TA337: Rifaximin for preventing episodes of overt hepatic encephalopathy
Link  NMUH: Trust guidelines on Management of Hepatic Encephalopathy
   
05.01.07  Fidaxomicin
Fidaxomicin
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Restricted Drug Restricted

Consultant microbiologist approval only for multiple recurrent Clostridium difficile infections (at least three). Fidaxomicin could also be used in patients in extremis when all other drugs had failed (October 2012)

Provider notes

  • NMUH:
    • Microbiology approval only
  • RFL:
    • Consultant microbiologist approval only  
  • RNOH:
    • Microbiology approval only
  • UCLH:
  • WH:
    • Microbiology approval only
 
   
05.01.08  Sulphonamides and trimethoprim
Co-trimoxazole
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • See Microguide for agreed indications
    • Approved for treatment and prevention of PCP infection; see Chemotherapy protocols
    • Microbiology or ID approval required for other indications
  • RNOH:
    • Oral suspension available as 40/200 mg/5mL and 80/400 mg/5mL
  • UCLH:
  • WH:
    • Microbiology approval only
 
   
Trimethoprim
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Formulary

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • No restriction stated
 
   
05.01.09  Antituberculosis drugs
Bedaquiline
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Formulary
GP - Red
High Cost Medicine
BlueTeq

Approved for XDR-TB and MDR-TB in line with the NHS England Clinical Commissioning Policy F04/P/a (JFC April 2017)

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Approved for XDR-TB and MDR-TB in line with NHSE policy
    • Restricted to ID team only
  • RNOH:
    • Non-formulary  
  • UCLH:
    • Pulmonary multidrug-resistant tuberculosis in line with NHS England policy, restricted to TB team
  • WH:
    • As above
 
Link  NHSE 170132P: Treatment for defined patients with MDR-TB and XDR-TB including bedaquiline and delamanid
   
Capreomycin
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Microbiology/ ID approval only (TB treatment)
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Restricted to TB clinic or as per Microbiology advice
 
   
Cycloserine
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Restricted for the use in combination with other drugs for Tuberculosis resistant to first line drugs only
  • RFL:
    • Microbiology/ ID approval only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Restricted to TB clinic or as per Microbiology advice
 
   
Delamanid
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Approved for XDR-TB and MDR-TB in line with the NHS England Clinical Commissioning Policy F04/P/a (JFC April 2017)

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • As per NHSE policy for XDR-TB and MDR-TB
  • RNOH:
    • Non-formulary  
  • UCLH:
    • Pulmonary multidrug-resistant tuberculosis in line with NHS England policy, restricted to TB team
  • WH:
    • TB clinic only
 
Link  NHSE 170132P: Treatment for defined patients with MDR-TB and XDR-TB including bedaquiline and delamanid
   
Ethambutol
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • No restriction stated (suspension 400mg/5ml [unlicensed] is available for the treatment of tuberculosis in children)
  • RFL:
    • For treatment of tuberculosis only
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • No restriction stated
 
   
Isoniazid
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • No restriction stated (Isoniazid elixir 50mg/5mL [unlicensed] available for the treatment of tuberculosis in children)
  • RFL:
    • For treatment and prophylaxis of tuberculosis only
    • Microbiology or ID approval required for other indications
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • No restriction stated
 
   
Pyrazinamide
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • No restriction stated (pyrazinamide 500mg/5mL suspension [unlicensed] available for the treatment of tuberculosis in children)
  • RFL:
    • For treatment of tuberculosis only  
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • No restriction stated
 
   
Rifabutin
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Restricted to AIDS patients use only
  • RFL:
    • For HIV / TB Consultant use only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • For HIV / TB Consultant use only
 
   
Rifampicin
(Antibacterial)
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Restricted Drug Restricted

NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • For treatment of tuberculosis only
    • Microbiology/ID approval required for all other indications
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Microbiology approval only
 
   
Rifampicin + Isoniazid (Rifinah® 150 & 300)
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • For treatment of tuberculosis only
    • Microbiology/ID approval only
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • No restriction stated
 
   
Rifampicin + Isoniazid + Pyrazinamide (Rifater®)
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • For treatment of tuberculosis only
    • Microbiology/ID approval only
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • TB / Microbiology approval only
 
   
Rifampicin + Isoniazid + Pyrazinamide + Ethambutol (Voractiv®)
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Formulary

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • For treatment of tuberculosis only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
   
Aminosalicylic acid
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Unlicensed Drug Unlicensed

Provider notes

  • NMUH:
    • Available from 'special order' manufacturers
  • RFL:
    • Available from 'special order' manufacturers
    • MDR-TB only
    • Restricted to ID / Microbiology
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
   
Protionamide
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Unlicensed Drug Unlicensed

Provider notes

  • NMUH:
    • For Multidrug resistent TB
    • To be prescribed by Respiratory Consultants ONLY
    • Protionamide 250mg tablets, Available from ‘special-order’ manufacturers or specialist importing companies
  • RFL:
    • Available from 'special order' manufacturers
    • MDR-TB only
    • Restricted to ID / Microbiology
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • For specialist use only
 
   
05.01.10  Antileprotic drugs
Clofazimine
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Microbiology approval only
 
   
Dapsone
(Anti-infective)
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Restricted Drug Restricted

NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
   
05.01.11  Metronidazole and tinidazole to top
Metronidazole
(Antibacterial)
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Formulary

NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • No restriction stated
 
   
Tinidazole
(Antibacterial)
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Restricted Drug Restricted

NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
   
05.01.12  Quinolones
Ciprofloxacin
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • See microguide for agreed indications
    • Microbiology approval required for all other indications
  • RNOH:
    • Oral suspension available as 250 mg/5mL
  • UCLH:
  • WH:
    • For restricted indications as per Trust guidelines or Microbiology advice
 
Link  NCL JFC: Safe prescribing of fluoroquinolones Position Statement
   
Levofloxacin
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Restricted to Consultant Microbiologist or Consultant Gastroenterologist recommendation
  • RFL:
    • Follow RFL microbiology guidelines for agreed indications
    • Microbiology approval required for all other indications
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • For restricted indications as per Trust guidelines or Microbiology advice
 
Link  NCL JFC: Safe prescribing of fluoroquinolones Position Statement
   
Moxifloxacin
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Restricted to microbiology and respiratory consultants
  • RFL:
    • Restricted to thoracic medicine / ID (TB) and Opthalmology
    • ID/Microbiology approval required for all other indications
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • For restricted indications as per Trust guidelines or Microbiology advice
 
Link  NCL JFC: Safe prescribing of fluoroquinolones Position Statement
   
Ofloxacin
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Approved for symptomatic gonorrhoea and pelvic inflammatory disease only
  • RFL:
    • Restricted to GUM
    • ID/Microbiology approval required for all other indications
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Link  NCL JFC: Safe prescribing of fluoroquinolones Position Statement
   
05.01.13  Urinary-tract infections
Methenamine hippurate
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Formulary

Approved for recurrent UTIs in adults who have experienced ≥ 2 UTIs in the last 6 months, or ≥ 3 in the last 12 months (JFC April 2017)

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • As per above JFC agreed indication  
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
   
Nitrofurantoin
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Formulary

Provider notes

  • NMUH:
    • See MHRA Drug Safety Update
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • No restriction stated
 
   
Nitrofurantoin modified release
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Formulary

Provider notes

  •  NMUH:
    • Non-formulary
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
    • Non-formulary
  •  WH:
    • No restriction stated
 
   
05.02  Antifungal drugs
Amphotericin infusion (Fungizone®)
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Formulary

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Not for intravenous use
    • Microbiology/ID approval only
  • RNOH:
    • Non-formulary
  • UCLH:
    • Approved for:
      • Cryptococcosis – treatment (Restricted to Microbiology approval)
      • Serious fungal infections (Restricted to Microbiology approval for intraventricular disease)
  • WH:
    • Non-formulary
 
   
Amphotericin liposomal infusion (AmBisome®)
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Restricted Drug Restricted
High Cost Medicine

Provider notes

  • NMUH:
    • As per Trust Guidelines
  • RFL:
    • Restricted to OLT prophylaxis (2nd transplant/hepatic artery thrombosis)
    • Microbiology/ID approval required for all other indications
  • RNOH:
    • Microbiology approval only
  • UCLH:
  • WH:
    • Microbiology approval only
 
   
Fluconazole
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Infusion restricted to Microbiology Consultants use only
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Restricted antifungal. Microbiology approval only
 
   
Flucytosine infusion
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • Restricted to Microbiology Consultants use only
  • RFL:
    • Microbiology / ID approval required 
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Microbiology approval only
 
   
Griseofulvin
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Formulary

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • No restriction stated
 
   
Itraconazole
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Oral: Restricted to Dermatology; HIV; Haematology. ID/Microbiology approval for all other indications.
    • Intravenous: Microbiology/ID approval
  • RNOH:
    • Microbiology approval only
  • UCLH:
  • WH:
    • For restricted indications as per Trust guidelines or Microbiology advice
 
   
Posaconazole
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • Non-formulary
    • See MHRA Drug Safety Updates
  • RFL:
    • Liquid: Restricted to Haematology and Oncology for prophylaxis; Microbiology approval required for treatment doses and all other indications
    • Tablets: Microbiology/ID approval required
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
   
Terbinafine tabs
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted

Provider notes

  • NMUH:
    • Restricted to Dermatology use only
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • No restriction stated
 
   
Voriconazole
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • Non-formulary
    • See MHRA Drug Safety Updates
  • RFL:
    • Microbiology approval required 
  • RNOH:
    • Microbiology approval required
  • UCLH:
  • WH:
    • Check with Microbiology
 
   
Flucytosine tablets
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Unlicensed Drug Unlicensed

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Microbiology / ID approval required
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • 500mg tablets
 
   
05.02  Treatment of fungal infections
05.02  Drugs used in fungal infections to top
05.02.01  Triazole antifungals
05.02.02  Imidazole antifungals
05.02.03  Polyene antifungals
05.02.04  Echinocandin antifungals
Anidulafungin
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Approved for invasive candidiasis, subject to local Antimicrobial Committee approval (JFC February 2019).

Provider notes

  • NMUH:
    • To be used as per Trust antifungal guidelines
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Microbiology approval only
 
   
Caspofungin
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • Microbiology consultant approval only
  • RFL:
    • See Microguide for agreed indications
    • Restricted to Haematology / Oncology as per policy
    • Microbiology approval required for all other indications.
  • RNOH:
    • Microbiology approval only
    • Store in a fridge
  • UCLH:
  • WH:
    • Reserved for prescribing by paediatric consultants only
 
   
05.02.05  Other antifungals to top
05.03  Antiviral drugs
05.03.01  HIV infection
Atazanavir + cobicistat (Evotaz®)
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • To be initiated by Consultants in HIV Medicine only
  • RFL:
    • HIV Medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Non-formulary
 
   
Cobicistat
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Second line protease inhibitor booster for HIV for confirmed ritonavir intolerance (March 2016)

Provider notes

  • NMUH:
    • To be initiated by Consultants in HIV Medicine only
    • See MHRA Drug Safety Updates
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
   
Rilpivirine + emtrictabine + tenofovir alafenamide (Odefsey®)
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Formulary
GP - Red

 Secondary care notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Link  NHSE 16043/P: Tenofovir Alafenamide for treatment of HIV 1 in adults and adolescents
   
Tenofovir alafenamide + Elvitegravir + Cobicistat + Emtricitabine (Genvoya®)
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • To be initiated by consultants in HIV medicines only
    • See MHRA Drug Safety Update
    • See link below
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Link  NHSE 16043/P: Tenofovir Alafenamide for treatment of HIV 1 in adults and adolescents
   
05.03.01  Nucleoside reverse transcriptase inhibitors
Abacavir
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • For TB / HIV clinic only
 
   
Abacavir + Lamivudine
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • To be prescribed as per BHIVA Guidelines by the HIV team only
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • For TB / HIV clinic only
 
   
Abacavir + Lamivudine + Zidovudine (Trizivir®)
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Formulary
GP - Red

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
   
Emtricitabine
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Formulary
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • To be prescribed as per BHIVA Guidelines by the HIV team only
    • Patients currently benefiting from FTC in their combination therapy, who either accessed FTC in studies or move to London with FTC as part of their existing regimen, should continue to receive FTC without interruption
    • For patients who have previously not received 3TC, the decision to prescribe 3TC or FTC to be made by the clinician and patient after discussion and consideration of relevant factors
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • For TB / HIV clinic only
 
   
Emtricitabine + Rilpivirine + Tenofovir disoproxil (Eviplera®)
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • NHSE approval required
    • Initiation restricted to Consultants HIV Medicine
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Non-formulary
 
   
Emtricitabine + Tenofovir alafenamide (Descovy®)
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Formulary
GP - Red

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Link  NHSE 16043/P: Tenofovir Alafenamide for treatment of HIV 1 in adults and adolescents
   
Lamivudine
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • Epivir brand only approved for HIV patients
    • Zeffix brand approved for HIV and Hepatitis B patients
  • RFL:
    • 150mg & 300mg approved for HIV patients
    • 100mg approved for Hepatitis B patients
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Epivir brand on formulary
 
   
Rilpivirine
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Formulary
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Non-formulary
 
   
Stavudine
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Formulary
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
   
Tenofovir disoproxil + Cobicistat + Elvitegravir + Emtricitabine (Stribild®)
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Formulary
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • See MHRA Drug Safety Update
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • For TB / HIV clinic only
 
Link  NHSE B06/P/x: Stribild® for the treatment of HIV-1 infection in adults
   
Tenofovir disoproxil + Efavirenz + Emtricitabine
View adult BNF View SPC online View childrens BNF
Formulary
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • To be prescribed by the HIV team only, in line with the BHIVA Guidelines
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • For TB / HIV clinic only
 
   
Tenofovir disoproxil + Emtricitabine
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Formulary
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • To be prescribed by the HIV team only, in line with the BHIVA Guidelines
  • RFL:
    • HIV medicine only
  • RNOH:
    • Restricted for use in accordance with RNOH Sharps Policy and Inoculation Management (see policy)
  • UCLH:
  • WH:
    • No restriction stated
 
Link  RNOH: Sharps Policy and Inoculation Management
   
Tenofovir disproxil
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Formulary
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Approved for HIV
    • Approved for Hepatitis B - see NICE TA
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NICE TA173: Hepatitis B (chronic) - tenofovir disoproxil
   
Zidovudine
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Zidovudine infusion is for use by Women’s Health only
    • Caps 100mg, 250mg; Infusion 200mg/2 ml only  
 
   
Zidovudine + Lamivudine
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Formulary
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • No restriction stated 
 
   
05.03.01  Protease inhibitors
Atazanavir
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • To be prescribed as per BHIVA Guidelines by HIV team only
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • No restriction stated
 
   
Darunavir
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • To be prescribed as per BHIVA Guidelines by the HIV team only
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • For TB / HIV clinic only
 
   
Darunavir + Cobicistat (Rezolsta®)
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Formulary
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • To be initiated by Consultants in HIV Medicine only
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Non-formulary
 
   
Darunavir + Cobicistat + Emtricitabine + Tenofovir alafenamide (Symtuza®)
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Formulary
GP - Red

Approved for HIV infection in line with NHSE commissioning policy F03/P/b (JFC January 2019)

 Provider notes

  • NMUH:
    • To be prescribed by the HIV team only, as per the clinical commissioning policy - see link below.
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Non-formulary
 
Link  NHSE F03/P/b: Use of cobicistat as a booster in treatment of HIV infection (all ages)
   
Fosamprenavir
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Formulary
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • No restriction stated
 
   
Lopinavir + Ritonavir
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Formulary
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • Check Drug Safety Update
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • For TB / HIV clinic only
 
   
Ritonavir
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Formulary
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • For TB / HIV clinic only
 
   
Saquinavir
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Formulary
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • No restriction stated
 
   
Tipranavir
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • To be prescribed as per BHIVA Guidelines by the HIV team only
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Non-formulary
 
   
05.03.01  Non-nucleoside reverse transcriptase inhibitors to top
Efavirenz
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Formulary
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • No restriction stated
 
   
Etravirine
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Formulary
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • To be prescribed as per BHIVA Guidelines by the HIV team only
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Non-formulary
 
   
Nevirapine
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • For TB/HIV clinic & Womens Health
 
   
05.03.01  Other antiretrovirals
Dolutegravir
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Formulary
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Non-formulary
 
Link  NHSE B06/P/a: Dolutegravir for treatment of HIV1 in adults and adolescents
   
Dolutegravir + Abacavir + Lamivudine (Triumeq®)
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Formulary
GP - Red
High Cost Medicine

Approved for HIV in line with NHSE Commissioning Policy B06/P/a.

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NHSE B06/P/a: Dolutegravir for treatment of HIV1 in adults and adolescents
   
Enfuvirtide
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • To be used in accordance with the London HIV consortium BHIVA guidelines
    • For HIV team only
    • Patients currently benefiting from enfuvirtide in their combination therapy should continue to receive enfuvirtide without interruption. Current benefit is defined as patients whose viral load is either undetectable or remaining below their pre-enfuvirtide baseline level. Patients whose current viral load has substantially rebounded or returned to their baseline level when their first used enfuvirtide and who have a strong CD4 count, are likely to have developed or be developing resistance to enfuvirtide. Enfuvirtide is also unlikely to be having antiretroviral activity, and these patients should consider stopping the enfuvirtide in their combination, with close monitoring BHIVA Guidelines - Treatment of HIV-1 infected adults with antiretroviral therapy
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Non-formulary
 
   
Maraviroc
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Non-formulary
 
   
Raltegravir
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • HIV medicine only
  • RNOH:
    • Restricted for use in accordance with RNOH Sharps Policy and Inoculation Management (see policy)
  • UCLH:
  • WH:
    • For TB / HIV clinic and post-exposure prophylaxis
 
Link  RNOH: Sharps Policy and Inoculation Management
   
05.03.02  Herpesvirus infections
05.03.02.01  Herpes simplex and varicella-zoster infection
Aciclovir
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • No restriction stated
 
   
Famciclovir
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Formulary

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • For Microbiology use only
 
   
Valaciclovir
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Formulary

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Follow virology/microbiology guidelines
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
   
05.03.02.02  Cytomegalovirus infection
Cidofovir infusion
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • HIV/Virology approval required
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
   
Foscarnet sodium IV
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • Restricted for HIV patients use only.
  • RFL:
    • Restricted to HIV; Transplant patients; Haematology; Oncology
    • Virology approval required for all other indications
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
   
Ganciclovir IV
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Restricted to HIV; Transplants; Other immunosuppressed patients
    • Virology approval required for all other indications
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Check with Microbiology
 
   
Valganciclovir
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Restricted to HIV; Transplants; Other immunosuppressed patients
    • Virology approval required for all other indications
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Restricted to Microbiology
 
   
Ganciclovir oral
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Restricted Drug Restricted
GP - Red

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Restricted to Microbiology
 
   
05.03.03  Viral hepatitis to top
05.03.03.01  Chronic hepatitis B
Adefovir Dipivoxil
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • This medicine has a positive NICE Technology Appraisal BUT IS NOT LISTED IN THE TRUST FORMULARY AS AN ALTERNATIVE NICE APPROVED MEDICINE IS USED.
  • RFL:
    • Restricted to Hepatology/Virology
    • As per NICE guidance
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NICE TA96: Hep B - adefovir dipivoxil and pegylated interferon alpha-2a
   
Entecavir
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Formulary
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • Positive NICE TA This medicine has a positive NICE Technology Appraisal and is listed in the Trust Medicines Formulary when used in line with NICE recommendations and/or Local Trust Guidelines.
    • See link below
  • RFL:
    • See NICE TA for eligibility criteria
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NICE TA153: Hepatitis B (chronic) - etecavir
   
05.03.03.02  Chronic hepatitis C
Dasabuvir
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • To be prescribed by Consultants Andrew Millar, Dimitra Doufexi and Jonathan Ainsworth only for Hepatitis C
    • See links below
    • Check MHRA Drug Safety Updates
  • RFL:
    • For use by Hepatology in the treatment of Hepatitis C in line with NICE guidance
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Link  NICE TA365: Ombitasvir–paritaprevir–ritonavir with or without dasabuvir for treating chronic hepatitis C
Link  NMUH: Pharmacy Guidelines for use of Direct Acting Antivirals
   
Elbasvir + Grazoprevir
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Restricted Drug Restricted
GP - Red
BlueTeq

Provider notes

  • NMUH:
    • This medicine has a positive NICE Technology Appraisal and is listed in the Trust Medicines Formulary when used in line with NICE recommendations and/or Local Trust Guidelines.
    • See links below
    • To be prescribed by Consultants Andrew Millar, Dimitra Doufexi and Jonathan Ainsworth ONLY for Hepatitis C.
  • RFL:
    • Approved for use by Hepatology in the treatment of Hepatitis C in line with NICE guidance
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NICE TA413: Elbasvir–grazoprevir for treating chronic hepatitis C
   
Glecaprevir + Pibrentasvir
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Formulary
GP - Red

Provider notes

  • NMUH:
    • This medicines has a positive NICE TA and will be included in the formulary once NMUH is able to provide this medicine VAT free.
  • RFL:
    • Approved for use by Hepatology for the treatment of Hepatitis C in line with NICE guidance
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NICE TA499: Glecaprevir–pibrentasvir for treating chronic hepatitis C
   
Ledipasvir + Sofosbuvir
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Restricted Drug Restricted
GP - Red
High Cost Medicine
BlueTeq

Provider notes

  • NMUH:
    • This medicine has a positive NICE Technology Appraisal and is listed in the Trust Medicines Formulary when used in line with NICE recommendations and/or Local Trust Guidelines.
    • See links below
    • To be prescribed by Consultants Andrew Millar, Dimitra Doufexi and Jonathan Ainsworth ONLY for Hepatitis C.
    • Check MHRA Drug Safety Updates
  • RFL:
    • Approved for use by Hepatology in the treatment of Hepatitis C in line with NICE guidance
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NICE TA363: Ledipasvir–sofosbuvir for treating chronic hepatitis C
Link  NMUH: Pharmacy Guidelines for use of Direct Acting Antivirals
   
Ombitasvir + paritaprevir + ritonavir (Viekirax®)
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Restricted Drug Restricted
GP - Red
High Cost Medicine
BlueTeq

Provider notes

  • NMUH:
    • This medicine has a positive NICE Technology Appraisal and is listed in the Trust Medicines Formulary when used in line with NICE recommendations and/or Local Trust Guidelines.
    • See links below
    • To be prescribed by Consultants Andrew Millar, Dimitra Doufexi nd Jonathan Ainsworth ONLY for Hepatitis C.
    • Check MHRA Drug Safety Updates
  • RFL:
    • Approved for use by Hepatology in the treatment of Hepatitis C in line with NICE guidance
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NICE TA365: Ombitasvir–paritaprevir–ritonavir with or without dasabuvir for treating chronic hepatitis C
Link  NMUH: Pharmacy Guidelines for use of Direct Acting Antivirals
   
Ribavirin
(Hepatitis)
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Restricted Drug Restricted
GP - Red
High Cost Medicine

NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Approved for hepatitis B (see NICE TA for eligibility criteria) and chronic hepatitis E viraemia in immunosuppressed individuals (JFC June 2016)

Provider notes

  • NMUH:
    • This medicine has a positive NICE Technology Appraisal and is listed in the Trust Medicines Formulary when used in line with NICE recommendations and/or Local Trust Guidelines
    • See links below
    • Ribavirin is listed on this formulary for treatment of chronic hepatitis C and for immunosuppressed individuals with chronic hepatitis E viraemia
    • Ribavirin should only be prescribed by Hepatologists
  • RFL:
    • Virology/Microbiology/ID approval only.
    • Hepatology use approved for the treatment of Hepatitis C in line with NICE guidance and Hepatitis E
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • As per JFC and NICE TA
    • Ribavirin should only be prescribed by Hepatologists
 
Link  NICE TA106: Hepatitis C - peginterferon alfa and ribavirin
Link  NICE TA200: Hepatitis C - peginterferon alfa and ribavirin
Link  NICE TA300: Hepatitis C - peginterferon alfa and ribavirin in children and young people
Link  NICE TA75: Hepatitis C - pegylated interferons, ribavirin and alfa interferon
   
Sofosbuvir
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Restricted Drug Restricted
GP - Red
High Cost Medicine
BlueTeq

Provider notes

  • NMUH:
    • This medicine has a positive NICE Technology Appraisal and is listed in the Trust Medicines Formulary when used in line with NICE recommendations and/or Local Trust Guidelines.
    • See links below
    • To be prescribed by Consultants Andrew Millar, Dimitra Doufexi and Jonathan Ainsworth ONLY for Hepatitis C.
    • Check MHRA Drug Safety Updates
  • RFL:
    • Approved for use by Hepatology in the treatment of Hepatitis C in line with NICE guidance
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NICE TA330: Sofosbuvir for treating chronic hepatitis C
Link  NMUH: Pharmacy Guidelines for use of Direct Acting Antivirals
   
Sofosbuvir + Velpatasvir
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Restricted Drug Restricted
GP - Red
BlueTeq

Provider notes

  • NMUH:
    • This medicine has a positive NICE Technology Appraisal and is listed in the Trust Medicines Formulary when used in line with NICE recommendations and/or Local Trust Guidelines.
    • See links below
    • To be prescribed by Consultants Andrew Millar, Dimitra Doufexi and Jonathan Ainsworth ONLY for Hepatitis C.
    • Check MHRA Drug Safety Updates
  • RFL:
    • Approved for use by Hepatology in the treatment of Hepatitis C in line with NICE guidance
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NICE TA430: Sofosbuvir–velpatasvir for treating chronic hepatitis C
Link  NMUH: Pharmacy Guidelines for use of Direct Acting Antivirals
   
Sofosbuvir + Velpatasvir + Voxilaprevir
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Restricted Drug Restricted
GP - Red

Provider notes

  • NMUH:
    • This medicines has a positive NICE TA and will be included in the formulary once NMUH is able to provide this medicine VAT free.
  • RFL:
    • Approved for use by Hepatology for the treatment of Hepatitis C in line with NICE guidance
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Link  NICE TA507: Sofosbuvir–velpatasvir–voxilaprevir for treating chronic hepatitis C
   
05.03.04  Influenza
Oseltamivir
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Restricted Drug Restricted

Provider notes

  • NMUH:
    • This medicine has a positive NICE Technology Appraisal and is listed in the Trust Medicines Formulary when used in line with NICE recommendations and/or Local Trust Guidelines.
    • Indicated for the prophylaxis and treatment of influenza, as per NICE guidelines
  • RFL:
    • Virology/Microbiology/ID approval only
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NICE TA158 (amantadine NOT recommended): Oseltamivir, amantadine (review) and zanamivir for the prophylaxis of influenza
Link  NICE TA168: Amantadine, oseltamivir and zanamivir for the treatment of influenza
   
Zanamivir inhalation
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Restricted Drug Restricted
GP - Red

Provider notes

  • NMUH:
    • This medicine has a positive NICE Technology Appraisal and is listed in the Trust Medicines Formulary when used in line with NICE recommendations and/or Local Trust Guidelines.
    • Indicated for the prophylaxis and treatment of influenza, as per NICE guidelines
  • RFL:
    • Virology/Microbiology/ID approval only
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • Microbiology approval only
 
Link  NICE TA158 (amantadine NOT recommended): Oseltamivir, amantadine (review) and zanamivir for the prophylaxis of influenza
Link  NICE TA168: Amantadine, oseltamivir and zanamivir for the treatment of influenza
   
Amantadine
(Influenza)
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Restricted Drug Restricted

NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Virology/Microbiology/ID approval only
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • Microbiologist approval only
 
Link  NICE TA158 (amantadine NOT recommended): Oseltamivir, amantadine (review) and zanamivir for the prophylaxis of influenza
Link  NICE TA168 (amantadine NOT recommended): Amantadine, oseltamivir and zanamivir for the treatment of influenza
   
Zanamivir injection
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Restricted Drug Restricted
GP - Red

Approved for for treatment of complicated and potentially life-threatening influenza A or B virus infection in patient's whose influenza virus is known or suspected to be resistant to anti-influenza medicinal products other than zanamivir, and/or other anti-viral medicinal products for treatment of influenza, including inhaled zanamivir, are not suitable for the individual patient (JFC September 2019).

Provider notes

  • NMUH:
    • Microbiology approval only
  • RFL:
    • Virology/Microbiology/ID approval only
  • RNOH:
    • Requires Microbiology approval
  • UCLH:
  • WH:
    • Microbiology approval only
 
   
05.03.05  Respiratory syncytial virus
Palivizumab
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Restricted Drug Restricted
GP - Red
High Cost Medicine

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Restricted to paediatrics and neonates
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
   
05.04  Antiprotozoal drugs to top
Metronidazole
(Antiprotozoal )
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Formulary

NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • Non-formulary  
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • No restriction stated
 
   
05.04.01  Antimalarials
Artesunate
(Antimalarial)
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Unlicensed Drug Unlicensed

Approved for severe falciparum malaria (November 2015) 

Provider notes

  • NMUH:
    • To be used on the recommendation of the Infectious Diseases Team or Microbiology according to the NMUHT malaria guidelines.
    • See link below
    • Available from ‘special-order’ manufacturers or specialist importing companies
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NMUH: Guidelines for Treatment of Malaria in Adult Patients
Link  NMUH: Guidelines for Treatment of Malaria in Paediatric Patients
Link  WH: Malaria Investigation and Treatment Guideline for Adults
   
05.04.01  Treatment of malaria
05.04.01  Falciparum malaria (treatment)
05.04.01  Benign malarias (treatment)
05.04.01  Prophylaxis against malaria to top
05.04.01  Specific recommendations
05.04.01  Artemether with lumefabtrine
Artemether + Lumefantrine
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Formulary

Provider notes

  • NMUH:
    • To be used as per the NMUHT Malaria Guidelines, see links below
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • First line for uncomplicated falciparum malaria, chloroquine-resistant non-falciparum malaria, and PO step down from IV artesunate
    • See link below
 
Link  NMUH: Guidelines for Treatment of malaria in Adult Patients
Link  NMUH: Guidelines for Treatment of Malaria in Paediatric Patients
Link  WH: Malaria Investigation and Treatment Guideline for Adults
   
05.04.01  Chloroquine
Chloroquine
(Antimalarial)
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Formulary

NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • To be used as per the NMUHT Malaria Guidelines, see links below
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NMUH: Guidelines for Treatment of Malaria in Adult Patients
Link  NMUH: Guidelines for Treatment of Malaria in Paediatric Patients
   
05.04.01  Mefloquine
Mefloquine
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted

Provider notes

  • NMUH:
    • Restricted to HIV patients only
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
   
05.04.01  Primaquine to top
Primaquine
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed

Provider notes

  • NMUH:
    • To be used as per NMUH Malaria Guidelines, see link below
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NMUH: Guidelines for Treatment of Malaria in Adult Patients
Link  NMUH: Guidelines for Treatment of Malaria in Paediatric Patients
   
05.04.01  Proguanil
Atovaquone + Proguanil
(Malaria)
View adult BNF View SPC online View childrens BNF
Formulary

Provider notes

  • NMUH:
    • To be used as per the NMUHT Malaria Guidelines
    • See link below
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
Link  NMUH: Guidelines for Treatment of malaria in Adult Patients
Link  NMUH: Guidelines for Treatment of Malaria in Paediatric Patients
   
Proguanil
View adult BNF View SPC online View childrens BNF
Formulary

Provider notes

  • NMUH:
    • To be used as per the NMUH malaria guidelines, see link below
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NMUH: Guidelines for Treatment of Malaria in Adult Patients
   
05.04.01  Pyrimethamine
Pyrimethamine
View adult BNF View SPC online View childrens BNF
Formulary

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • For Microbiology use only
 
   
Pyrimethamine + Sulfadoxine
View adult BNF View SPC online View childrens BNF
Formulary

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
   
05.04.01  Quinine
Quinine
(Antimalarial)
View adult BNF View SPC online View childrens BNF
Protected Drug Protected

NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • See link(s) below
  • RFL:
    • No restriction stated
  • RNOH:
    • Includes sulphate and bisulphate preparations
  • UCLH:
  • WH:
    • Qunine can accumulate with long term use and cause toxicity

 

 
Link  NMUH: Guidelines for Treatment of Malaria in Adult Patients
Link  NMUH: Guidelines for Treatment of Malaria in Paediatric Patients
   
Quinine dihydrochloride
(Antimalarial)
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed

NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • See link below
  • RFL:
    • No restriction stated
  • RNOH:
    • TBC
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NMUH: Guidelines for Treatment of Malaria in Adult Patients
Link  NMUH: Guidelines for Treatment of Malaria in Paediatric Patients
   
05.04.01  Tetracyclines
Doxycycline
(Antimalarial)
View adult BNF View SPC online View childrens BNF
Formulary

NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • See link below
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
Link  NMUH: Guidelines for Treatment of Malaria in Adult Patients
Link  NMUH: Guidelines for Treatment of Malaria in Paediatric Patients
   
05.04.02  Amoebicides to top
Tinidazole
(Antiprotozoal )
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted

NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • Non-formulary  
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
   
05.04.03  Trichomonacides
05.04.04  Antigiardial drugs
Mepacrine Hydrochloride
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed

Provider notes

  • NMUH:
    • Restricted to Rheumatology Consultants
  • RFL:
    • Restricted to Rheumatology, Dermatology, Microbiology or Infectious Diseases consultants
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
   
05.04.05  Leishmaniacides
05.04.06  Trypanocides
05.04.07  Drugs for toxoplasmosis to top
Sulfadiazine
View adult BNF View SPC online View childrens BNF
Formulary

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
   
05.04.08  Drugs for pneumocystis pneumonia
Atovaquone
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
GP - Red

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • For Microbiology use only
 
   
Pentamidine isetionate
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
GP - Red

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • For Microbiology use only
 
   
05.04.08  Treatment
05.04.08  Prophylaxis
05.05  Anthelmintics
05.05.01  Drugs for threadworms to top
Mebendazole
View adult BNF View SPC online View childrens BNF
Formulary

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • No restriction stated
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • No restriction stated
 
   
Albendazole
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed

Provider notes

  • NMUH:
    • For use for named patients only
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
   
05.05.02  Ascaricides
05.05.03  Drugs for tapeworm infections
05.05.03  Taenicides
05.05.03  Hydatid disease
05.05.04  Drugs for hookworms to top
05.05.05  Schistosomicides
Praziquantel
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
   
05.05.06  Filaricides
05.05.07  Drugs for cutaneous larva migrans
Ivermectin tablets
(Anthelmintics)
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed

Provider notes

  • NMUH:
    • 3mg tablets available from 'special order'
  • RFL:
    • No restriction stated
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • No restriction stated
 
   
05.05.08  Drugs for strongyloidiasis
05.06  Unlicensed Medicines / Significant off-label use to top
Taurolodine and Citrate 4% (TauroLock®)
View childrens BNF
Restricted Drug Restricted

Approved for recurrent catheter-releated bloodstream infections. Restricted to patients who have had ≥ 2 CRBI in 6 months or ≥ 3 CRBI in 12 months  (August 2015)

 

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • As above
 
   
Nitazoxanide
View childrens BNF
Unlicensed Drug Unlicensed
High Cost Medicine

Nitazoxanide for chronic resistant norovirus infection in PID patients – Approved for prescribing by Immunology only (JFC August 2013)

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • For chronic resistant norovirus infection in PID patients
    • Restricted to immunology only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
   
Pristinamycin tablets
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Microbiology/ID approval only
  • RNOH:
    • Microbiologist approval only for the treatment of joint infection
    • This medicine is not licensed in the UK
    • 500mg tablets
  • UCLH:
  • WH:
    • Non-formulary
 
   
Spectinomycin injection
View childrens BNF
Unlicensed Drug Unlicensed

Provider notes

  • NMUH:
    • Restricted to Consultants in GU Medicine only
    • Should only be used in penicillin-allergic patients
    • Available from ‘special-order’ manufacturers or specialist importing companies
  • RFL:
    • Restricted to TB
    • All other indications require Microbiology / ID or thoracics approval required
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Microbiology approval required
 
   
Spiramycin
(Toxoplasmosis)
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Restricted to ID/Microbiology only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Advice of Microbiology only
 
   
Streptomycin sulphate
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • Restricted to TB
    • All other indications require Microbiology / ID or thoracics approval required
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Streptomycin injection available after microbiology approval
 
   
Triclabendazole
(Human Fascioliasis)
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed
GP - Red

Approved for Human Fascioliasis Infection (JFC April 2019)

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • As per indication above
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
 
   
 ....
 Non Formulary Items
Aciclovir lauriad  (Sitavig)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Amphotericin lipid complex infusion  (Abelcet®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
 
Ampicillin

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Aztreonam nebuliser solution  (Cayston®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
 
Cefaclor

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Cefadroxil

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Cefradine

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Ceftaroline

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Ceftobiprole

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Cefuroxime Axetil

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Chloroquine + Proguanil

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Clarithromycin modified release

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Co-Fluampicil  (Ampicillin + Flucloxacillin)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Colistimethate inhaler  (Colobreathe®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
Link  NICE TA276: Cystic fibrosis (pseudomonas lung infection) - colistimethate sodium and tobramycin
 
Collatamp EG Sponge

View adult BNF View SPC online View childrens BNF
Non Formulary
Black

Not approved for osteomyelitis (JFC May 2016)

 
Diloxanide

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Doravirine + Lamivudine + Tenofovir disoproxil  (Delstrigo®)

View adult BNF View SPC online View childrens BNF
Non Formulary
GP - Red

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
Link  NHSE 190137P: Doravirine for the treatment of HIV-1 in adults
 
Doravirine tabs  (Pifeltro®)

View adult BNF View SPC online View childrens BNF
Non Formulary
GP - Red

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary
Link  NHSE 190137P: Doravirine for the treatment of HIV-1 in adults
 
Inosine Pranobex

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Isavuconazole

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Ketoconazole tablets
(Antifungal)

View adult BNF View SPC online View childrens BNF
Non Formulary

NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

License withdrawn for this indication

 
Letermovir tabs

View adult BNF View SPC online View childrens BNF
Non Formulary
GP - Red

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
    • Non-formulary
  • WH:
    • Non-formulary
Link  NICE TA591: Letermovir for preventing cytomegalovirus disease after a stem cell transplant
 
Levofloxacin nebuliser  (Quinsair®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
Link  NCL JFC: Safe prescribing of fluoroquinolones Position Statement
 
Micafungin

View adult BNF View SPC online View childrens BNF
Non Formulary
GP - Red
High Cost Medicine
 
Nalidixic Acid

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Netilmicin  (Netillin®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Niclosamide

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Norfloxacin

View adult BNF View SPC online View childrens BNF
Non Formulary
Link  NCL JFC: Safe prescribing of fluoroquinolones Position Statement
 
Oritavancin  (Orbactiv®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Piperaquine + Artenimol  (Eurartesim®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Piperazine

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Quinupristin and dalfopristin  (Synercid®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Sinecatechins  (Veregen)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Sodium Stibogluconate

View adult BNF View SPC online View childrens BNF
Non Formulary
 
SPL7013  (VivaGel®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Tedizolid

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Telavancin

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Telbivudine

View adult BNF View SPC online View childrens BNF
Non Formulary
GP - Red
Link  NICE TA154 (not recommended): Telbivudine for the treatment of chronic hepatitis B
 
Telithromycin  (Ketek®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
TIABENDAZOLE 500mg tabs

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Ticarcillin + Clavulanic acid

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Tobramycin inhaler
(Cystic fibrosis)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
Link  NICE TA276: Cystic fibrosis (pseudomonas lung infection) - colistimethate sodium and tobramycin
 
Tobramycin nebuliser
(Cystic fibrosis)

View adult BNF View SPC online View childrens BNF
Non Formulary

NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

 
Tobramycin nebuliser
(Non-CF bronchiectasis)

View adult BNF View SPC online View childrens BNF
Non Formulary
Black
High Cost Medicine

NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Not approved for non-CF bronchiectasis (April 2017)

 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

GP - 1st

Medicines suitable for first-line use within primary care.

Can be initiated within primary care within their licensed indication, in accordance with nationally recognised formularies, for example the BNF, BNF for Children, Medicines for Children or Palliative Care Formulary. Primary care prescribers take full responsibility for prescribing. 

  

GP - 2nd

Medicines suitable for second-line use within primary care.

Can be initiated within primary care within their licensed indication, in accordance with nationally recognised formularies, for example the BNF, BNF for Children, Medicines for Children or Palliative Care Formulary. Primary care prescribers take full responsibility for prescribing. 

  

GP - Amber

Medicines that should be initiated by a specialist. Prescribing can be transferred to primary care once the patient has been stabilised.  

Shared care: For drugs with regular, ongoing need for monitoring and/or assessment of efficacy or toxicity. Prior agreement must be obtained by the specialist from the primary care provider before prescribing responsibility is transferred. The shared care protocol must have been agreed by the relevant secondary care trust Drugs and Therapeutics Committee(s) (DTC) and approved by the North Central London JFC.

Fact sheet: For drugs with some concerns surrounding safety or efficacy but do not require regular monitoring and/or monitoring of effectiveness/toxicity.

  

GP - Red

Medicines which should normally be prescribed by specialists only (hospital only).

For patients already receiving prescriptions in primary care - continue. No new patients to receive prescriptions in primary care.

See link for the complete NCL Red List https://www.ncl-mon.nhs.uk/wp-content/uploads/2017/08/ncl_red_list.pdf

  

GP - Grey

Medicines on hospital formularies which have not been reviewed for suitability in primary care.  

Black

Medicines not recommended for routine use in primary or secondary care.

Medicines, which the North Central London JFC has actively reviewed and does not recommend for use at present due to limited clinical and/or cost effective data.

  

netFormulary