| Formulary Chapter 4: Central nervous system - Full Chapter
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| 04.02.01 |
Antipsychotic Drugs |
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| 04.02.01 |
First-Generation Antipsychotic Drugs |
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| 04.02.01 |
Second-Generation Antipsychotic Drugs |
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Aripiprazole
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 Restricted
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  (hospital only prescribing) for aripiprazole intramuscular injection
 for aripiprazole oral formulations
Approved (7.5mg/1mL IM formulation) for the rapid control of agitation and disturbed behaviours in adult patients with schizophrenia or with manic episodes in Bipolar I Disorder when oral therapy is not appropriate and where IM haloperidol is not recommended (JFC January 2019).
Provider notes
- NMUH:
- As per indication stated above for IM formulation, after psychiatry advise only
- Oral formulation are on the formulary for continuation only. Not to be initiated at NMUH
- RFL:
- Restricted for initiation until after a discussion with liaison psychiatry team
- RNOH:
- Initiation with Psychiatry advice only
- UCLH:
- WH:
- Restricted for initiation by a Consultant Psychiatrist only
- CIFT:
- Approved for
- Mania
- Schizophrenia
- Persistent aggression in moderate to severe Alzheimer’s dementia where risk of harm to self & others (off-label)
- Depression (adjunctive treatment)
- Challenging behaviour in learning disabilities - 2nd line
- BEHMT:
- Approved for
- Mania
- Schizophrenia
- Rapid tranquillisation
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Olanzapine
(Antipsychotic)
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Restricted
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NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications.
Provider notes
- NMUH:
- Restricted to Psychiatric department use only
- Only for third line treatment of schizophrenia after using standard antipsychotics and risperidone
- RFL:
- Restricted for initiation until after a discussion with liaison psychiatry team
- RNOH:
- UCLH:
- WH:
- Restricted for initiation by a Consultant Psychiatrist only
- CIFT
- BEHMT
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Lurasidone
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Non Formulary
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Not approved for schizophrenia (June 2015) |
Key |
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High Cost Medicine
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Cancer Drugs Fund
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NHS England |
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Homecare |
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CCG |
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Traffic Light Status Information
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Description |
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Medicines suitable for first-line use within primary care.
Can be initiated within primary care within their licensed indication, in accordance with nationally recognised formularies, for example the BNF, BNF for Children, Medicines for Children or Palliative Care Formulary. Primary care prescribers take full responsibility for prescribing. |
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Medicines suitable for second-line use within primary care.
Can be initiated within primary care within their licensed indication, in accordance with nationally recognised formularies, for example the BNF, BNF for Children, Medicines for Children or Palliative Care Formulary. Primary care prescribers take full responsibility for prescribing. |
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Medicines that should be initiated by a specialist. Prescribing can be transferred to primary care once the patient has been stabilised.
Shared care: For drugs with regular, ongoing need for monitoring and/or assessment of efficacy or toxicity. Prior agreement must be obtained by the specialist from the primary care provider before prescribing responsibility is transferred. The shared care protocol must have been agreed by the relevant secondary care trust Drugs and Therapeutics Committee(s) (DTC) and approved by the North Central London JFC.
Fact sheet: For drugs with some concerns surrounding safety or efficacy but do not require regular monitoring and/or monitoring of effectiveness/toxicity. |
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Medicines which should normally be prescribed by specialists only (hospital only).
For patients already receiving prescriptions in primary care - continue. No new patients to receive prescriptions in primary care. |
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Medicines on hospital formularies which have not been reviewed for suitability in primary care. |
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Medicines not recommended for routine use in primary or secondary care.
Medicines, which the North Central London JFC has actively reviewed and does not recommend for use at present due to limited clinical and/or cost effective data. |
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